动脉硬化闭塞症患者股动脉粥样硬化斑块中血管内皮生长因子、内皮抑素、微血管密度的表达及意义  

Expression and clinical significance of VEGF ,ENS and MVD in atherosclerosis plaque of femoral artery in patients with atherosclerosis obliterans

作　　者：穆鑫[1] 刘少奎[1] 王筱梅[1] 洪军[1] 初楠[1] 陈仕毅[1] 

机构地区：[1]大连大学附属中山医院心内科,116001

出　　处：《中国综合临床》2011年第6期582-584,共3页Clinical Medicine of China

摘　　要：目的探讨血管内皮生长因子（VEGF）、内皮抑素（ENS）与微血管密度（MVD）值及下肢动脉硬化的关系。方法以2007年10月至2010年8月我院收治30例动脉硬化闭塞症患者股动脉为实验组，另取同期22例外伤截肢患者股动脉为对照组。应用免疫组织化学法测定动脉硬化闭塞症患者股动脉硬化斑块中VEGF和ENS及MVD的表达。结果实验组中VEGF、ENS和MVD的表达明显高于对照组[分别为2．24±0．31比1．87±0．27，t=3．58；1．84±0．41比1．56±0．38，t=2．09；（8．79±2．46）条／HP比（6．05±1．68）条／HP，t：3．64；P〈0．01或P〈0．05]。VEGF、VEGF／ENS与MVD的表达分别呈正相关（r=0．391，P〈0．01；r=0．583，P〈0．05），而ENS与MVD的表达呈负相关（r=-0．328，P〈0．05）。结论VEGF促进动脉粥样斑块中新生血管的生成，ENS则起抑制作用，它们的共同作用仍导致血管新生。Objective To investigate the relationship between the expressions of VEGF,ENS, MVD and arteriosclerosis （AS） plaque in atherosclerosis obliterans （ASO） patients. Methods Immunohistochemieal staining was used to determine the expression of VEGF, ENS and MVD value in the atheroselerosis plaque of ASO patients hospitalized from October 2007 to August 2010 in our hospital （n =30） ,and the femoral arterials of control were collected from 22 amputation after traumatic injury. Results The expressions of VEGF （2. 24±0. 31 vs. 1.87±0. 27, t = 3.58 ）, ENS （ 1.84±0. 41 vs. 1.56±0. 38, t = 2. 09 ） and MVD value （ 8.79±2.46 slip/HP vs. 6.05±1.68 slip/HP, t = 3.64 ） were significantly higher in the AS plaque of ASO patient than control （ P 〈 0. 01 or P 〈 0. 05 ）. We found positive correlations between the expression of VEGF, VEGF/ENS with MVD （ r = 0. 391, P 〈 0. 01 ; r = 0. 583,P 〈 0. 05 ）, while negative correlation between the expression of ENS with MVD （ r = - 0. 328, P 〈 0. 05 ）. Conclusion VEGF promotes the angiogenesis in atherosclerosis plaque, while ENS shows opposite effect. The comprehensive performance of them is promoting angiogenesis.

关 键 词：血管内皮生长因子 内皮抑素 微血管密度 动脉硬化闭塞症 

分 类 号：R543.5[医药卫生—心血管疾病]