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作 者:乔薇[1] 陈蕾[1] 焦媛[2] 陈莉[2] 张小平[1]
机构地区:[1]中日友好医院干部保健病房,北京100029 [2]中日友好医院心内科,北京100029
出 处:《中国综合临床》2011年第6期589-592,共4页Clinical Medicine of China
摘 要:目的应用定量组织速度成像(QTVI)技术及脑钠肽(BNP)的测定,评价增龄对左心室收缩及舒张功能的影响。方法将60例年龄36~82岁的正常健康人分为〈60岁组(32例)与≥60岁组(28例),对比2组传统心脏超声、QTVI、BNP指标,分析增龄与传统超声参数、QTVI参数及BNP之间的关系。结果年龄i〉60岁组与年龄〈60岁组比较,二尖瓣口舒张早期与舒张晚期血流速度比(E/A)(0.92±0.18、1.28±0.18)、二尖瓣环6个位点平均收缩期峰值速度(Sm)[(6.044-0.77)、(6.89±1.03)cm/s]、平均舒张早期峰值速度(Em)[(5.67±0.99)、(7.29±I.11)cm/s]、平均舒张早期与舒张晚期峰值速度比(Em/Am)[(0.79±0.13)、(1.18±0.33)]明显减低(t值分别为5.396、2.478、4.075、3.535,P均〈0.05),平均舒张晚期峰值速度(Am)[(7.67±0.80)、(6.80±1.16)cm/s]、二尖瓣口舒张早期血流速度与二尖瓣环平均舒张早期峰值速度比(E/Em)[(14.83±4.43)、(10.68±2.85)]、BNP[(51.25±12.21)、(14.154-6.68)ng/L]明显升高(t值分别为-2.268、-2.995、-3.523,P均〈0.05)。年龄与平均Sm、平均Em、平均Em/Am、E/A呈负相关(r值分别为-0.411、-0.631、-0.622、-0.614,P均〈0.05),与平均Am、平均E/Em、BNP呈正相关(r值分别0.481、0.614、0.684,P均〈0.05)。结论增龄使左心室收缩及舒张功能均受损,OTVI及BNP检查评价心室功能敏感而简便易行。Objective To evaluate the influence of aging on left ventricular systolic and diastolic function by quantitative tissue velocity image(QTVI) and B-type natriuretic peptide (BNP). Methods Sixty healthy participants aged from 36 to 82 years old were divided into age 〈60 years group (32 cases) and age≥60 years old group (28 cases). Compared traditional echocardiography, QTVI and BNP between the two groups, and analysised the correlation between age and the abovementioned measurements. Results Compared age ≥ 60 years group with age 〈 60 years group, the ratio of early to late mitral annulus flow velocity(E/A) (0. 92±0. 18 vs. 1.28±0. 18), mean of systolic mitral annulus velocity (Sin) ( [ 6. 04±0. 77 ] cm/s vs. [ 6.89±1.03 3 cm/ s), mean of early diastolic mitral annulus velocity (Em) ( [ 5.67±0. 99 ] cm/s vs. [ 7.29±1.11 ] cm/s), the ratio of Em to Am (Em/Am) (0. 79±0. 13 vs. 1.18±0. 33 ) were significantly decreased ( t = 5. 396,2. 478, 4. 075,3. 535, respectively, Ps 〈 0. 05 ), whereas mean of late diastolic mitral annulus velocity (Am) ( [ 7. 67±0. 80] cm/s VS. [ 6. 80 ±1.16 ] cm/s), the ratio of E to Em (E/Em) ( 14. 83±4.43 vs. 10. 68±2. 85), BNP ( [51.25± 12.21 ] ng/L vs. [ 14. 15 + 6.68 ] ng/L) were significantly increased ( t = - 2. 268, - 2. 995 and - 3. 523, Ps 〈 0. 05 ). Age was negatively correlated with Sm, Em, Em/Am, E/A ( r = - 0. 411, - 0. 631, -0. 622, -0. 614,Ps 〈0. 05) ,and age was positively correlated with Am,E/Em and BNP (r = 0. 481,0. 614 and 0. 684,Ps 〈 0. 05). Conclusion Left ventricular systolic and diastolic function decreased with aging. QTVI and BNP could evaluate left ventricutar function sensitively and easily.
分 类 号:R540.4[医药卫生—心血管疾病]
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