β-Catenin、E-cadherin和APC在卵巢上皮肿瘤中的表达  

Expression of beta-catenin,E-cadherin and APC in ovarian epithelial tumors

作　　者：魏德娥[1] 仲文玉[1] 魏树珍[1] 马轶飞[1] 

机构地区：[1]山东大学附属济南市中心医院妇产科,济南250013

出　　处：《山东大学学报（医学版）》2011年第5期71-74,共4页Journal of Shandong University:Health Sciences

摘　　要：目的分析卵巢恶性上皮性肿瘤、交界性上皮肿瘤、良性上皮性肿瘤中β-连环素(β-catenin)、E-钙黏蛋白(E-cadherin)、结肠腺瘤样息肉病(APC)蛋白的表达,研究其在上皮性卵巢肿瘤发生过程中的作用,探讨Wnt信号通路在上皮性卵巢肿瘤中发挥作用的可能性。方法应用免疫组织化学染色SABC法检测49例卵巢恶性上皮性肿瘤、10例卵巢交界性上皮肿瘤及16例卵巢良性上皮肿瘤组织中的β-catenin、E-cadherin和APC蛋白的表达情况,并分析其相关性。结果在卵巢恶性上皮性肿瘤中β-catenin、E-cadherin的异常表达率(79.59%、67.35%)明显高于卵巢交界性上皮肿瘤(30%、20%)和卵巢良性上皮肿瘤(25%、0%)。β-catenin的表达与E-cadherin的表达呈正相关(R=0.525 8,P<0.05)。而卵巢恶性上皮性肿瘤中APC的阴性表达率明显高于卵巢良性上皮肿瘤(P<0.05),而与卵巢交界性上皮肿瘤间差异无统计学意义(P>0.05)。卵巢恶性上皮性肿瘤中β-catenin的表达与APC的表达无显著相关性(R=0.042 9,P>0.05)。结论β-catenin、E-cadherin、APC在卵巢恶性上皮性肿瘤的发生发展中可能发挥重要作用,但传统的Wnt信号通路在上皮性卵巢肿瘤中发挥作用的可能性不大。Objectives To investigate expression of β-catenin,E-cadherin and APC in ovarian epithelial tumors, and its implication in oncogenesis,and to investigate the effects of the Wnt signal pathway in ovarian oncogenesis. Methods Immunohistochemical staining with the SABC procedure was conducted to examine expression of-β-catenin, E-cadherin and APC in 75 specimens： 49 for epithelial ovarian carcinoma,10 marginal ovarian tumor and 16 benign ovarian tumor. Results Expression of β-catenin and E-cadherin in ovarian malignant epithelial tumors was higher than in both ovarian borderline epithelial tumors and benign epithelial tumors.In ovarian epithelial tumors,a significantly positive correlation was found between β-catenin and E-cadherin in their expression（P〈0.01）.The prevalence of APC positive in benign epithelial tumors was significantly greater than in malignant epithelial tumors（P〈0.05）, while there was no positive correlation between malignant epithelial tumors and borderline epithelial tumors（P〉0.05）. Statistically, there was no relationship between β-catenin and APC in malignant epithelial tumors（P〉0.05）. Conclusion β-catenin, E-cadherin and APC protein have important effects on pathogenesis and development of ovarian epithelial tumors.By contrast, the Wnt signal pathway may not contribute to these processes.

关 键 词：卵巢肿瘤 连环素 上皮性钙黏附因子 结肠腺瘤样息肉病蛋白 WNT信号通路 

分 类 号：R711[医药卫生—妇产科学]