血清IL-8水平测定在子宫内膜异位症诊断中的价值  

The significance of serum IL-8 level in diagnosis of endometriosis

作　　者：杨琦[1] 孙伟莉[2] 袁媛[2] 李卫鹏[2] 陶健[2] 刘健[3] 

机构地区：[1]蚌埠医学院生化与分子生物学教研室临床检验诊断学实验中心,233030 [2]蚌埠医学院第一附属医院核医学科,233030 [3]蚌埠医学院第一附属医院妇瘤科,233030

出　　处：《免疫学杂志》2011年第6期507-509,共3页Immunological Journal

摘　　要：目的探讨测定血清中的白介素8(IL-8)在诊断子宫内膜异位症中的价值。方法酶联免疫吸附法测定80例未经手术的子宫内膜异位症患者外周血IL-8浓度,并与60例正常体检者相比较。微粒子酶免疫发光法测定患者以及对照组的血清CA-125浓度,比较IL-8与CA-125在诊断子宫内膜异位症方面的灵敏度。结果子宫内膜异位症患者外周血IL-8浓度显著高于对照组(P<0.05),在诊断子宫内膜异位症方面,IL-8的临界值为26 pg/ml时,其诊断子宫内膜异位症方面的灵敏度要显著高于CA-125(71.3%vs 56.3%,P<0.05)。结论测定血清IL-8浓度是诊断子宫内膜异位症的一个有价值的指标。This study aimed to evaluate the value of serum interleukin（IL）-8 levels in diagnosis of endometriosis.Total of 80 patients with endometriosis and 60 healthy controls were recruited in this study.Preoperative blood samples were collected from 80 patients.Then IL-8 and CA-125 levels in the serum was measured by ELISA and microparticle enzyme immunoassay,respectively.We found that the serum concentration of IL-8 in patients with endometriosis was significantly higher than that in healthy controls.The serum IL-8 threshold（26 pg/ml） had a higher sensitivity（71.3%） for diagnosing endometriosis as compared with serum CA-125.Thus,we concluded that measuring of serum IL-8 concentration may be a valuable tool in diagnosing endometriosis.

关 键 词：子宫内膜异位症 白介素-8 CA-125 

分 类 号：R711.71[医药卫生—妇产科学]