上海市某医院新生儿脐带血中多溴联苯醚水平及其对出生结局的影响  

Concentration of polybrominated diphenyl ethers in umbilical cord serum and the influence on newborns birth outcomes in Shanghai

作　　者：张琳[1] 田英[1] 杨先丰 崔昌[1] 高宇[3] 王筱金[4] 王沛[5] 丁问微[6] 施蓉[3] 王英[6] 金军[6] 金萍[3] 

机构地区：[1]上海交通大学医学院公共卫生学院环境卫生学教研室 上海市环境与儿童健康教育部重点实验室,200025 [2]潍坊人民医院滨海分院 [3]上海交通大学医学院公共卫生学院环境卫生学教研室,200025 [4]上海交通大学医学院公共卫生学院生物统计学教研室,200025 [5]上海市浦东新区疾病预防控制中心高桥分中心 [6]中央民族大学生命与环境科学学院

出　　处：《中华预防医学杂志》2011年第6期490-493,共4页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金（30872086）;上海市卫生局基金（08GWD11）

摘　　要：目的 调查上海市某医院新生儿脐带血中多溴联苯醚（polybrominated diphenyl ethers,PBDEs）浓度水平,并分析胎儿期PBDEs暴露对新生儿出生结局的影响.方法 于2006年9月至2007年4月,对上海市某医院50名入院分娩的孕妇进行问卷调查,孕妇均为单胎妊娠,排除高血压、糖尿病、HIV感染和不良药物史.收集新生儿脐带血样本,使用气相色谱-负化学电离源-质谱法检测脐带血中7种PBDEs[溴代联苯醚（BDE）-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183]浓度,计算PBDEs总浓度（∑,PBDEs）,并进一步分析脐带血中PBDEs浓度水平对新生儿出生结局的影响.结果 上海市某医院新生儿身长为（50.15±0.75）cm,体重为（3.49±0.42）kg,胸围为（34.76±1.51）cm,头围为（35.03±1.40）cm,体质指数为（13.76±1.36）kg/m2.新生儿脐带血中∑,PBDEs中位数浓度（范围）为14.06（1.03～379.73）ng/g脂重（lipid weight,1w）.BDE-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183检出率分别为22%（11/50）、22%（11/50）、98%（49/50）、72%（36/50）、76%（38/50）、90%（45/50）、14%（7/50）.各同族体中位数浓度（范围）分别为：BDE-28为〈检测限（LOD）（＜LOD～137.20 ng/g 1w）,BDE-47为＜LOD（＜LOD-33.17 ng/g 1w）,BDE-99为7.54（＜LOD-94.01）ng/g 1w,BDE-100为1.57（＜LOD-46.95）ng/g 1w,BDE-153为0.63（＜LOD-79.08）ng/g 1w,BDE-154为0.63（＜LOD-22.30）ng/g 1w,BDE-183为＜LOD（＜LOD-21.63 ng/g 1w）.新生儿体质指数与BDE-99（r=-0.347,P＜0.05）和BDE-154（r=-0.292,P＜0.05）浓度呈负相关.将出生结局按照累计频率25%分为低（≤25%）、高（＞25%）两组,BDE-99在低身长组（≤50 cm）和高身长组（＜50 cm）的几何均数分别为10.59 ng/g 1w和3.60 ng/g 1w,二者差异有统计学意义（t=2.32,P=0.03）.结论 上海市某医院新生儿脐带血中普遍存在PBDEs,胎儿期PBDEs暴露可影响新生儿出生结局.Objective To explore the concentration of polybrominated diphenyl ethers（PBDEs）in umbilical cord serum and analyze the influence of exposure to PBDEs during fetal stage on newborn birth outcomes in Shanghai.Methods Fifty delivery women in a Shanghai hospital were surveyed by questionnaire.and the umbilical cord serum were collected from September 2006 to April 2007.All the delivery women were singleton pregnancies,excluding hish blood pressure,diabetes,HIV infection and adverse medical history.Seven congeners（BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154 and BDE-183） were measured by gas chromatography-negative chemical ionization-mass spectrometry and the influencing factors were anatyzed. Results Newborns＇length.weight,chest circumference,head circumference and body mass index（BMI）were（50.15±0.75）cm,（3.49±0.42）kg,（34.76±1.51）cm,（35.03 ±1.40）cm,（13.76±1.36）kg/m2,respectively.The median of ∑7 PBDEs concentration in umbilical cord serum was 14.06（1.03-379.73）ng/g lipid weight（1w）.The detection rate of BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154 and BDE-183 were 22%（11/50）,22%（11/50）,98%（49/50）.72%（36/50）,76%（38/50）,90%（45/50）and 14%（7/50）,respectively.The median（range）of PBDEs （BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154,BDE-183）congeners were ＜LOD （＜LOD-137.20 ng/g 1w）,＜LOD（＜LOD-33.17 ng/g 1w）,7.54.ng/g 1w（＜LOD-94.01 ng/g 1w）,1.57 ng/g 1w（＜LOD-46.95 ng/g 1w）,0.63.ng/g 1w（＜LOD-79.08 ng/g 1w）,0.63 ng/g 1w（＜LOD-22.30 ng/g 1w）and＜LOD（＜LOD-21.63 ng/g 1w）,respectiveIy.The newborns＇BMI showed a negative correlation with BDE-99（r=-0.347.P＜0.05）and BDE.154（r=-0.292.P＜0.05）.BDE-99in low-length group（≤50 cm,10.59 ng/g 1w） was significantly higher（t=2.32,P=0.03）than that in high-length group（＞50 cm,3.60 ng/g 1w）.Conclusion PBDEs were commonly detected in newborns＇umbilical cord serum in this study.Our findings indicated that exposure to PBDEs adversely affected

关 键 词：多溴联苯类 婴儿 新生 胎血 胚胎发育 

分 类 号：R722.1[医药卫生—儿科]