上海某医院产妇乳汁中六溴环十二烷水平及新生儿经母乳日摄入量的监测分析  

Levels of hexabromocyclododecane in human breast-milk and the daily intake of newborns in a Shanghai hospital

作　　者：丁问微[1] 田英[2] 金军[1] 王英[1] 崔昌[2] 张琳[2] 高宇[2] 王筱金[3] 施蓉[2] 

机构地区：[1]中央民族大学生命与环境科学学院,北京100081 [2]上海交通大学医学院公共卫生学院环境教研室 上海市环境与儿童健康教育部重点实验室 [3]上海交通大学医学院公共卫生学院生物统计学教研室

出　　处：《中华预防医学杂志》2011年第6期498-501,共4页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金（30872086）;上海市卫生局基金（08GWD11）;高等学校学科创新引智计划项目（B08044）

摘　　要：目的 测定上海市某医院产妇乳汁中六溴环十二烷（hexabromocyclododecane,HBCD）含量水平,并估算新生儿每日经母乳HBCD摄人量.方法 于2006年9月至2007年4月在上海市城郊地区某三级甲等医院对分娩后的产妇进行问卷调查,并收集母乳样品48个,产妇均为单胎妊娠,排除高血压、糖尿病、HIV 感染和不良用药史.采用液相色谱-电喷雾离子源-串联三重四极杆质谱法测定α-HBCD,β-HBCD,γ-HBCD 3种非对映异构体的含量,并通过模型估算新生儿经母乳HBCD日摄入量.结果 上海市某医院产妇母乳中总HBCD浓度范围为0.11-37.75 ng/g脂重（lipid weight,1w）,中位数为1.42 ng/g 1w,在79%（38/48）的样品中被检出.其中α-HBCD含量最高,浓度中位数为1.24 ng/g 1w,在77%（37/48）的样品中检出;其次为γ-HBCD、β-HBCD,浓度中位数均小于检测限,分别在13%（6/48）,17%（7148）的样品中检出.新生儿经母乳总HBCD日摄人为：0.71-243.46 ng/kg.结论 上海市某医院产妇母乳中HBCD含量水平较高,其对婴幼儿健康的影响值得进一步研究.Objective To explore the level of hexabromocyclododecane （HBCD） in human breast milk of delivery women in a Shanghai hospital, and estimate the daily intake of newborns from breast milk. Methods Forty-eight delivery women in a Shanghai suburb hospital （Class A, Grade 3 ） were surveyed by questionnaires, and their breast milk samples were collected from September 2006 to April 2007. All the delivery women were singleton pregnancies, excluding high blood pressure, diabetes, HIV infection and adverse medical history. Three diastereoisomers （α-HBCD, β-HBCD,γ-HBCD） were measured by the liquid chromatography-electrospray ion source-tandem mass spectrometry,and then esitmated the daily intake of the newborns from the breast milk. Results The total HBCD concentration of breast milk, which was detected in 79% （38/48） of samples,ranged from 0. 11 ng/g lipid weight （lw） to 37.75 ng/g lw, with the median at 1.42 ng/g lw. The most abundant diastereoisomer was α-HBCD which detected in 77% （37/48） of samples, with a median of 1.24 ng/g lw ; followed by γ-HBCD and β-HBCD, detected in 13 % （6/48） and 17% （8/48） of samples respectively,whose median were both under the limit of detection （LOD）. The daily intake of the newborns from the breast milk ranged from 0. 71 ng/kg to 243.46 ng/kg. Conclusion The concentrations of HBCD in breast milk of delivery women in a Shanghai hospital have been in a high level, and the influence on newborns＇ health need to be further studied.

关 键 词：烃类 溴化 乳 人 婴儿 新生 母亲暴露 

分 类 号：R174[医药卫生—妇幼卫生保健]