中国人群CCR5△32、CCR2-64I、SDF1-3’A基因多态性与HIV-1感染相关性的Meta分析  

Association of CCR5,CCR2 and SDF1 gene polymorphisms with HIV-1 infection in Chinese population:a meta-analysis

作　　者：贺小峰[1] 贾宇静[2] 苏娇[3] 陈清[1] 朱文昌[1] 俞守义[1] 

机构地区：[1]南方医科大学公共卫生与热带医学学院流行病学系,广东广州510515 [2]南方医科大学珠江医院门诊部,广东广州510282 [3]长治医学院生物化学教研室,山西长治046000

出　　处：《南方医科大学学报》2011年第5期791-795,共5页Journal of Southern Medical University

基　　金：十一五国家科技攻关重大项目(2009ZX10001-0187);广州市科技攻关重点项目(2006Z1-E0091)~~

摘　　要：目的探讨中国人群CCR5△32、CCR2-64I、SDF1-3'A三种基因的多态性与HIV-1感染之间的关系。方法检索国内外有关中国人群CCR5△32、CCR2-64I、SDF1-3'A基因多态性与HIV感染相关性的病例对照研究文献并进行Meta分析。结果符合CCR5△32的研究共14个,累计HIV感染者病例1607例,正常对照组1632例。杂合子(wt/mt)、纯合子(mt/mt)和杂合子加纯合子(wt/mt+mt/mt)与野生基因型(wt/wt)相比合并的OR值(95%CI)分别为1.156(0.808,1.654)、0.997(0.198,5.022)、1.149(0.808,1.634)。符合CCR2-64I的研究共12个,累计HIV感染者病例1415例,正常对照组1239例。杂合子(wt/mt)、纯合子(mt/mt)和杂合子加纯合子(wt/mt+mt/mt)与野生基因型(wt/wt)相比合并的OR值(95%CI)分别为1.005(0.844,1.197)、1.191(0.808,1.754)、1.028(0.870,1.214)。符合SDFl-3'A的研究10个,累计HIV感染者病例1179例,正常对照组1003例。杂合子(wt/mt)、纯合子(mt/wt)和纯合子加杂合子(wt/mt+mt/mt)与野生基因型(wt/wt)相比合并的OR值(95%CI)分别为1.010(0.830,1.228)、1.188(0.860,1.643)、1.038(0.861,1.250)。结论中国人群CCR5△32、CCR2-64I、SDFl-3'A三种抗性基因与HIV-1感染之间无相关性,显示CCR5△32、CCR2-641、SDFl-3'A三种基因对中国人群HIV-1感染可能不具有保护作用,提示中国人群可能为易感人群。Objective To explore the association of CCR5△32,CCR2-64I and SDFl-3’A gene polymorphisms with HIV-1-infection in Chinese population. Methods A meta-analysis was performed to identify case-control studies of CCR5△32,CCR2-64I and SDFl-3’A polymorphisms from the literatures. Results Fourteen studies of CCR5△32 were found,involving a total of 1607 cases and 1632 controls. Compared with the wild-type homozygote wt/wt,the pooled odds ratios（95%CI） of wt/mt,mt/mt,and wt/mt＋mt/mt genotypes of CCR5△32 gene polymorphisms were 1.156（0.808,1.654） ,0.997（0.198,5.022） ,and 1.149（0.808,1.634） ,respectively. Twelve studies of CCR2-64I were identified,including 1415 cases and 1239 controls. Compared with the wild-type homozygote wt/wt,the pooled odds ratios（95%CI） of wt/mt,mt/mt,and wt/mt＋mt/mt genotypes of CCR2-64I gene polymorphisms were 1.005（0.844,1.197） ,1.191（0.808,1.754） ,and 1.028（0.870,1.214） ,respectively. Ten studies of SDFl-3＇A were found,involving 1179 cases and 1003 controls. Compared with the wild-type homozygote wt/wt,the pooled odds ratios（95%CI） of wt/mt,mt/mt,and wt/mt ＋ mt/mt genotypes of SDF1-3’A gene polymorphisms were 1.010（0.830,1.228） ,1.188（0.860,1.643） ,and 1.038（0.861,1.250） . Conclusion CCR5△32,CCR2-64I and SDFl-3’A gene polymorphisms do not show strong correlations to HIV-1-infection in Chinese population. These 3 genes may not have protective effect against HIV-1 infection in Chinese population,suggesting the susceptibility of Chinese population to the infection.

关 键 词：艾滋病病毒-1 CCR5 CCR2 SDF 基因多态性 

分 类 号：R512.91[医药卫生—内科学]