小气道炎症-肺气肿组织Ⅳ型胶原酶的表达  

Expression of Type Ⅳ Collagenase in Pulmonary Tissues in Rabbit Model of Small Airway Inflammation-emphysema

作　　者：辛建保[1] 胡道松[2] 张建初[1] 周小琴 向敏[1] 茹立强 

机构地区：[1]同济医科大学附属协和医院内科,武汉430022 [2]同济医科大学实验医学研究中心神经生物学教研室,武汉430030

出　　处：《同济医科大学学报》1999年第6期486-488,共3页Acta Universitatis Medicinae Tongji

摘　　要：分别用硝酸（硝酸组）和弹力酶（蛋白酶组）滴入兔气管复制出小气道炎症-肺气肿和局限性肺气肿动物模型。观察Ⅳ型胶原酶和金属蛋白酶组织抑制因子（TIMP）在肺气肿组织中的表达。结果显示硝酸组和蛋白酶组扩张的肺泡壁Ⅳ型胶原酶和TIMP的表达均明显增强。提示Ⅳ型胶原酶与肺气肿的发病有关。A rabbit model of small airway inflammation-emphysema was developed through dripping nitric acid (nitric acid group) and a model of local emphysema by dripping elastinase (elastinase group) . Expression of type Ⅳ collagenase and tissue inhibitors of metalloproteinases (TIMP) was detected in emphysematous tissues.The results showed that expression of type Ⅳ collagenase and TIMP was significantly increased in pulmonary tissues in both nitric acid group and papin group. It was suggested that type Ⅳ collagenase and TIMP were related to the development of emphysema.

关 键 词：肺气肿 胶原酶 小气道炎症 

分 类 号：R563.302[医药卫生—呼吸系统]