丝裂霉素C抑制实验性兔角膜新生血管形态学改变的研究  

Mitomycin C Inhibiting the Morphological Changes of Experimental Rabbit's Corneal Neovascularization

作　　者：赵长松[1] 沈远平[1] 

机构地区：[1]同济医科大学附属同济医院眼科,武汉430030

出　　处：《同济医科大学学报》1999年第6期509-511,514,共4页Acta Universitatis Medicinae Tongji

摘　　要：采用角膜缝线方法，诱导8只家兔16只眼角膜新生血管形成。缝线后的第3d，将丝裂霉素C和生理盐水分别注射于家兔眼结膜下，观察每眼角膜新生血管生长情况及组织病理学改变，以探讨丝裂霉素C抑制角膜新生血管的作用机制、结果：丝裂霉素组新生血管的长度明显短于对照组，差异有极显著意义（P＜0．01）；光镜下见浆细胞少；电镜下见新生血管内皮细胞变性。结果表明，丝裂霉素C结膜下注射抑制角膜新生血管的作用，可能是通过控制炎症增生和破坏新生血管内皮细胞来实现的。Corneal neovascularization was induced in 8 rabbits (16 eyes) by means of stitching cornea. On the 3rd after manipulaiton, mitomycin C and normal saline were separately injected into subconjunctival tissues to observe the growth of corneal neovascularization and histopathological changes to further investigate the mechanism of mytomycin C inhibiting corneal neovascularization. The results showed that in mitomycin group shorter elongation of neovascular growth in mitomycin C group was found (P<0. 01 ), fewer plasmocytes observed under the light microscope and degeneration of endothelial cells under the transmission electron microscope. The results indicated the subconjunctival injection of mitomycin. C could inhibit corneal neovascularization, which was probably attributed to the controling of inflammatory proliferation and destroying of endothelial cells.

关 键 词：角膜 新生血管 丝裂霉素C 形态学改变 

分 类 号：R979.1[医药卫生—药品] R322.9[医药卫生—药学]