心肌三磷酸腺苷依赖性钾通道在心肌缺血预适应中的作用  

The Role of Myocardial ATP-dependent Potassium Channel in Myocardial Ischemic Preconditioning

作　　者：彭雯[1] 张银环[1] 

机构地区：[1]同济医科大学附属协和医院综合科,武汉430022

出　　处：《同济医科大学学报》1999年第6期515-516,519,共3页Acta Universitatis Medicinae Tongji

摘　　要：为了验证三磷酸腺苷依赖性钾通道（KATP）的开放在兔心肌缺血预适应中的作用，将32只大白兔随机分为4组，每组8只：对照组，优降糖组，预适应组，优降糖＋预适应组。结果发现：预适应能缩小心肌梗死的范围［（7．40±1．48）％、（39．50±6．26）％］，而优降糖能取消这一作用［（37．20±6．86）％、（39．50±6．26）％］。优降糖为KATP的特异拮抗剂，说明KATP的开放是心肌缺血预适应的一个重要偶联机制。In order to study the role of opening myocardial ATP-dependent potassium (KATP) channel (KATP) in myocardial ischemia preconditioning in rabbit heart, 32 rabbits were randomly divided into 4 groups (8 in each): control, glibenclamide, preconditioned and glibenclamide+preconditioned. The result showed that preconditioning could reduce the infarct size of the myocardium [ (7. 40±1. 48) % vs (39. 50 ± 6. 26) % ], administration of glibenclamide before preconditioning completely abolished the protective effect [ (37. 20±6. 86) % vs (39. 50 ± 6. 26) %]. It was suggested that opening KATP channel might play an important role in the coupling mechanism of preconditioning in rabbit heart.

关 键 词：心肌缺血 预适应 三磷酸腺苷 钾通道 

分 类 号：R542.2[医药卫生—心血管疾病] R329.2[医药卫生—内科学]