海南省蜉蝣过敏原临床致敏性  

Allergenicity of Ephemeroptera Allergen in Allergic Rhinitis Patients of Hainan Province

作　　者：孟光[1] 刘硕[1] 李春林[1] 谢伟伟[1] 张淑芳[1,2] 蔡琼香[1] 邓晓聪[1] 

机构地区：[1]海南省海口市人民医院耳鼻喉科,海口570208 [2]海口市人民医院中心实验室,海口570208

出　　处：《中华临床免疫和变态反应杂志》2011年第2期113-116,I0002,共5页Chinese Journal of Allergy & Clinical Immunology

基　　金：海南省自然科学基金(30871);海口市重点科技计划项目(海科立2007-0080号);海南省卫生厅科研项目(琼卫2007-79)

摘　　要：目的了解海南省临床蜉蝣过敏情况,为过敏性鼻炎的流行病学研究及临床诊断、治疗和预防提供依据。方法对500例过敏性鼻炎患者用蜉蝣过敏原进行前臂皮肤点刺试验,然后随机选择20例蜉蝣点刺阳性患者进行蜉蝣过敏原鼻黏膜激发试验。结果 500例皮肤点刺试验中,蜉蝣阳性者占58.6%(293/500),20例阴性对照者皮肤点刺均为阴性100%(20/20);20例蜉蝣皮肤点刺阳性患者中过敏原鼻黏膜激发试验阳性者为20例(100%),20例阴性对照未见阳性反应。结论皮肤点刺和过敏原鼻黏膜激发试验结果相符合,蜉蝣为海南省重要过敏原。Objective To investigate the allergenicity of Ephemeroptera allergen in allergic rhinitis （AR） patients of Hainan province,as a basis for epidemiological survey,clinical diagnosis,treatment and prevention.Methods 500 patients with allergic rhinitis were detected with Ephemeroptera allergen extract by skin prick test （SPT）,and 20 cases of the SPT positive patients were chosen randomly to be prescribed the nasal provocation test.Allergen extract was produced by Beijing MacroUnion Pharmaceutical Co.,Ltd.Results 293 cases in AR group showed positive SPT results;the positive rate was 58.6% （293/500）.All the SPT results were negative in 20 cases in control group;the negative rate was 100% （20/20）.All the nasal provocation test results were positive in 20 cases positive SPT patients,while all negative in 20 cases of control group.Conclusion The SPT results were shown to accord with the results of nasal provocation test.Ephemeropterais one kind of important inhalant allergens in Hainan province,which provide evidence as a basis for clinical diagnosis,treatment,prevention and specific immunotherapy in allergic disease patients in Hainan province.

关 键 词：蜉蝣 过敏性鼻炎 过敏原 皮肤点刺试验 鼻黏膜激发试验 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]