血管紧张素转换酶基因插入/缺失多态性与冠心病关系的初步研究  

The Relationship between Angiotensin-Converting Enzyme Gene Polymorphism and Coronary Heart Disease

作　　者：隋建华[1] 李文辉[2] 彭晓[3] 雷仁义[3] 

机构地区：[1]天津,中国医学科学院,中国协和医科大学血液学研究所,300020 [2]北京,中国医学科学院,中国协和医科大学基础医学研究所 [3]兰州医学院第一附属医院

出　　处：《天津医药》1999年第12期707-710,共4页Tianjin Medical Journal

摘　　要：目的：研究中国汉族人群血管紧张素转换酶（ＡＣＥ）基因插入／缺失（Ｉ／Ｄ）多态性与冠心病的关系。方法：应用聚合酶链反应（ＰＣＲ）检测４０例冠心病和５０例配伍对照组的血管紧张素转换酶（ＡＣＥ）基因型，同时测血压、血脂、体重指数等指标。结果：冠心病组与对照组ＡＣＥ基因型分布无显著性差异，ＤＤ型对ＤＩ型和Ⅱ型优势比ＯＲ＝１．５２，９５％可信区间为０．５５～４．２２，Ｐ＞０．０５。结论：ＡＣＥ基因Ｉ／Ｄ多态性与中国汉族人群冠心病的发生无关，也不是有价值的遗传标志。Purpose: In order to investigate the relationship between insertion/deletion(I/D)polymorphism of angiotensin-convert- ing enzyme(ACE)gene and coronary heart diseade(CHD)in Chinese Han population.Methods:The genotype of ACE was examined by polymerase chain reaction (PCR)in 40 patients with CHD and 50 matched subjects.Results:The results showed that the distribution of ACE genotype was not significantly different between the cases and controls.The odd ratio for CHD with DD genotype compared with Ⅱ and DI genotype was 1.25(95% percent confidence limit,0.55-4.22,P>0.05).Conclusion: The results indicated that I/D polymorphism of ACE gene may not be involved in the pathogenesis of CHD,and not be a useful genetic marker for CHD in Chinese Han people.

关 键 词：冠心病 ACE 基因多态性 

分 类 号：R541.4[医药卫生—心血管疾病]