甲基黄酮醇胺对大鼠心室肌细胞钙电流的影响  

Effect of methylflavonolamine on calcium current in rat ventricular myocytes

作　　者：武冬梅[1] 张炜芳[1] 吕吉元[1] 吴博威[1] 

机构地区：[1]山西医科大学生理学教研室,太原030001

出　　处：《山西医科大学学报》1999年第4期289-290,共2页Journal of Shanxi Medical University

摘　　要：采用胶原酶Ｂ急性分离大鼠心室肌细胞。利用膜片钳技术，观察甲基黄酮醇胺对心肌细胞膜钙离子通道的影响。结果表明：甲基黄酮醇胺１ 、１０ 和５０ μｍｏｌ／Ｌ可剂量依赖性地抑制大鼠心室肌细胞膜钙离子电流，表明甲基黄酮醇胺有钙拮抗作用。Effect of methylflavonolamine(MEA) on calcium current ( I Ca ) was studied in single rat ventricular myocytes using whole cell patch clamp technique. It was demonstrated that MFA inhibited the I Ca in a dose-dependent manner.This result indicates that MFA is able to block calcium channel and has calcium antagonistic activity.

关 键 词：甲基黄酮醇胺 心肌 钙通道 抗心律失常药 

分 类 号：R972.2[医药卫生—药品]