三甲基氯硅烷催化合成2-芳基苯并咪唑的研究  

Study of the Synthesis of 2-Aryl Benzimidazoles Catalyzed by TMSCl

作　　者：张宗磊[1] 张燕[1] 吴过[1] 孙倩[1] 王存德[1] 

机构地区：[1]扬州大学化学化工学院,江苏扬州225002

出　　处：《化学世界》2011年第6期349-351,361,共4页Chemical World

摘　　要：采用三甲基氯硅烷（TMSCl）作为路易斯催化剂催化芳醛和邻苯二胺合成了2-芳基苯并咪唑化合物。以苯甲醛和邻苯二胺的反应为模型反应,考察了催化剂与反应底物质量比、反应温度和反应溶剂对反应效果的影响,验证了三甲基氯硅烷对合成反应的催化作用。实验结果表明,三甲基氯硅烷能大大加快芳醛和邻苯二胺合成2-芳基苯并咪唑反应的进行,其合成的适宜条件为：温度60-80℃,芳醛和邻苯二胺物质量比为1.0∶1.0（mol）,催化剂三甲基氯硅烷用量为10%mol反应底物芳胺,溶剂选用DMF,反应时间为6-8 h,能够获得收率为64.0%-91.1%的目标化合物。Some 2-aryl benzimidazoles were synthesized from o-benzenediamine and substituted benzaldehydes in the presence of TMSCl in DMF.The influence of reaction conditions on yields was also tested using the reaction of benzaldehyde and aniline as a model reaction,and the optimum conditions were as follows∶the mole ratio of substituted aniline∶substituted benzaldehyde∶TMSCl =1.0∶1.0∶0.1,the reaction temperature at 60-80 °C,and the reaction time of 6-8 h.Under the optimum conditions,the desired products were obtained with the yield of 64.0%-91.1%.

关 键 词：2-芳基苯并咪唑 三甲基氯硅烷 合成 催化 

分 类 号：O622.6[理学—有机化学]