16种中药的抗4NQO致突变作用  

Antimutagenicity of 16 kinds Chinese Herbal Drugs to 4NQO Induced Mutagenisis

作　　者：郭峻[1] 金中初[1] 梅汝焕[1] 

机构地区：[1]浙江大学医学院病理生理学教研室,杭州310006

出　　处：《中国公共卫生》1999年第12期1068-1070,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金

摘　　要：用Ｅ．ｃｏｌｉ ＣＭ８９１ 菌株的正向突变（ＳＭｒ－ ５） 和回复突变（ＴｒＰ＋） 双重指标，以细胞内抗突变作用的模式检测了１６ 种中药水提取物的抗４ ＮＱＯ 的致突变活性。结果显示：诃子、首乌、女贞子和带蒂菱壳具有拮抗４ ＮＱＯ 诱发的正向突变和回复突变的作用；带蒂菱壳还具有抗自发正向和回复突变的作用。白芍具有促进４ ＮＱＯAntimutagenicity effects of 16 Kinds Chinese Herbal Drugs on a dual biological indicators forward(SM r 5) and reversion(Trp +)mutations induced by 4 nitroquinoline 1 oxide(4NQO)were determined by a bioantimutagenic model in Escherichia coli strain CM891,respectely.Results showed the water extract of Fructus chebulae,Radix polygoni multiflori,Fructurs ligustri lucidi and shell of water chestnut with a pedicle could produce antimutagenisis against 4NQU induced forward and reversion mutation.Futher,shell of water chestnut with a pedicle also could do antimutagenisis to spontaneous ones.However,Paeonia lactiflora could prolmote 4NQO induced mutation.

关 键 词：中药 抗4NQO 抗突变作用 

分 类 号：R285.5[医药卫生—中药学]