血浆组织因子途径抑制物水平与肺血栓栓塞症相关性研究  

Level of tissue factor pathway inhibitor in pulmonary thromboemlism

作　　者：王崇刚[1] 关志明[1] 刘秀娥[2] 张玲[2] 侯丽虹[2] 

机构地区：[1]山西医科大学第二医院呼吸科,太原030001 [2]山西医科大学第二医院血液科,太原030001

出　　处：《中国药物与临床》2011年第6期624-626,共3页Chinese Remedies & Clinics

基　　金：山西省自然科学基金(2010011050-6)

摘　　要：目的探讨血浆组织因子途径抑制物(TFPI)水平与肺血栓栓塞症(PTE)的关系。方法选择PTE患者35例,健康对照组34名。采用全自动血凝分析仪检测TFPI的活性、酶联免疫吸附试验(ELISA)法进行TFPI抗原测定。结果 PTE患者血浆TFPI活性、截短TFPI抗原、总TFPI抗原和全长TFPI抗原与对照组比较,差异均无统计学意义(P>0.05)。结论 PTE患者血浆TFPI活性及其抗原活性可能与PTE发病无明显相关性。Objective To investigate the relationship between altered levels of tissue factor pathway inhibitor （TFPI） and pulmonary thromboemlism （PTE）.Methods Thirty five cases of PTE and 34 normal controls were examined for TFPI activity and TFPI antigen level using ELISA and one-stage clotting assay.Results The levels of TFPI：Ac,tr-TFPI：Ag,t-TFPI：Ag and f-TFPI：Ag were not statistically different between PTE patients and normal controls （P 0.05）.Conclusion The activity and antigen of TFPI may not be correlated with development of PTE.

关 键 词：肺栓塞 凝血致活酶 组织因子途径抑制物抗原 

分 类 号：R543.2[医药卫生—心血管疾病]