194名人类免疫缺陷病毒阳性孕妇分娩婴儿人类免疫缺陷病毒感染状态及生长发育分析  

Analysis of HIV status and growth during 194 HIV-positive pregnant women′s babies

作　　者：于兰[1] 唐志荣[1] 刘丽芬[1] 刘燕芬[1] 杨瑞侃[1] 窦艳云[1] 张福杰[1] 

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,100050

出　　处：《山西医药杂志（上半月）》2011年第6期549-551,共3页Shanxi Medical Journal

摘　　要：目的了解广西壮族自治区人类免疫缺陷病毒（HIV）阳性孕妇分娩婴儿的HIV感染、死亡及生长发育情况。方法针对在2006年10月至2009年2月广西壮族自治区4个市、县发现的194名HIV阳性孕妇分娩婴儿在1~18个月开展生长发育监测,同时分别在1、4和18个月提供HIV DNA检测和HIV抗体筛查,记录并分析婴儿HIV感染、死亡及生长发育情况。结果 HIV阳性孕妇分娩婴儿194名,179名有确定早期诊断结果的婴儿中,早期诊断HIV阳性13名,其中11名抗体检测阳性,2名死于早产和肺炎没有抗体检测结果;早期诊断HIV阴性中163名抗体检测阴性,3名没有抗体检测结果。10名没有确定早期诊断结果的婴儿中,6名抗体阴性,4名没有抗体检测结果。5名没有早期诊断结果的婴儿中,1名抗体检测阳性,4名没有抗体检测结果早期诊断与抗体检测一致率为100%。194名婴儿合计死亡7名,其中HIV早期诊断和抗体检测均阳性1例,2例早期诊断阳性抗体未测,1名早期诊断阴性抗体检测未做,3例早期诊断和抗体检测均未做,排除HIV阳性婴儿中失访的2例,HIV阳性婴儿病死率为2/11,早期诊断HIV阴性婴儿中排除失访4名,无一名婴儿死亡。HIV阳性孕妇分娩婴儿生长发育指标明显低于世界卫生组织2006年颁布的标准。结论为HIV阳性孕产分娩婴儿提供HIV早期诊断是尽早发现婴儿HIV感染的可行、有效方法;HIV阳性孕妇分娩婴儿生长发育指标明显低于WHO标准,应加强监测并采取综合干预措施。Objective To analyze HIV status,death and growth development in 194 infants delivered by HIV positive pregnant women.Methods To monitor growth development of these 194 infants born to HIV-infected mothers under 18 months,and to screen HIV DNA and HIV antibody tests in 1,4 and 18 months respectively,then HIV status,death and growth development of these HIV-exposed infants were recorded and analyzed,from Oct.2006 to Feb.2009 in Guangxi.Results There are 179 infants who have definite HIV-positive results by early infant diagnosis（HIV DNA 2 times）,13 of them were HIV DNA positive,antibody test was done in 11 infants and all were positive.There were 166 diagnosed as HIV DNA negative,163 got antibody test and were all negative.Ten infants had one HIV DNA negative result,then antibody test was done in 6 of them and all appeared negative.Five infants didn＇t test HIV DNA,and only one of them had antibody test and it was positive.The coincident rate of early infant diagnosis and antibody test is 100%.Seven infants died among these 194 infants,1 infant was diagnosed HIV positive by both early infant diagnosis and antibody test,2 of them had 2 HIV DNA positive results but no antibody test,1 had only one HIV DNA results and no antibody test was done.Three of them didn＇t have any HIV diagnostic tests.Two lost follow up.The mortality rate of HIV-positive infants is 2/11,there are no death in HIV-negative infants except 4 lost follow up.The indicators of growth development of HIV-exposed infants are lower than the criteria in WHO 2006.Conclusion Early infant diagnosis is the feasible,effective method to verify HIV infection among HIV-exposed infants;the indicators of growth development of HIV-exposed infants are lower than the criteria in WHO 2006,which suggested close monitoring and integrated intervention measures.

关 键 词：HIV 孕妇 诊断 

分 类 号：R512.91[医药卫生—内科学]