杭白菊水提取物对犬急性心肌梗死后缺血心肌的保护作用  

Effects of Water Extract of Dendranthema Morifolium on Myocardial ischemia in Canines

作　　者：黄浩[1] 郭环宇[1] 金红峰[1] 

机构地区：[1]浙江医院,杭州310013

出　　处：《浙江中西医结合杂志》2011年第5期307-310,共4页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:观察杭白菊水提取物对犬急性心肌梗死后缺血心肌的保护作用。方法:健康成年比格(Beagle)犬24只,随机分成假手术组、急性心肌梗死模型组,杭白菊水提物低、高剂量组,每组6只。观察杭白菊水提物对犬急性心肌梗死后梗死面积、重量、心肌损伤标志性酶以及炎症因子IL-6和TNF-α水平的影响。结果:与模型组比较,低、高剂量的杭白菊水提物组可明显降低犬急性心肌梗死后2周血清TNF-α、IL-6水平(P<0.05,P<0.01),降低梗死区重量(P<0.05),减少梗死区面积(P<0.01)。结论:杭白菊水提物对缺血损伤心肌有明显保护作用。杭白菊水提物,可能通过抑制炎症因子的产生、聚集和释放起到对缺血心肌的保护作用。Objective： To investigate the effect of water extract of Dendranthema Morifolium（DM） on the Protection of Myocardium from Ischemia Injury in Canines.Methods： The model of acute myocardial infarction（AMI） was established in adult Beagle canines.Canines were divided into 4 groups： sham group,AMI group,and AMI＋DM1 group（DM at the dose of 17 mg/kg）and AMI＋DM2（DM at the dose of 68 mg/kg）group,6 in each.The intervention time was 2 weeks.The ration of infarct area to risk area was examined and calculated,and enzymes as creatine kinase（CK-MB） and lactate dehydrogenase（LDH）,and inflammatory factors as IL-6 and tumor necrosis factor-α（TNF-α） were determined after the intervention of water extract of DM.Results： After the 2-week treatment with DM,the ration of infarct area to risk area,the infarct area weight,the levels of TNF-αand IL-6 were reduced as compared with the AMI group（P0.01,P0.05,P0.05,and P0.01,respectively） was decreased as compared with the AMI group.Conclusion： Water extract of DM may ameliorate myocardial ischemia injury by downregulating the level of inflammatory factors.

关 键 词：犬 急性心肌梗死 缺血心肌 细胞因子 杭白菊水提物 

分 类 号：R285.5[医药卫生—中药学]