厄贝沙坦对老年慢性充血性心衰患者心功能及脑钠肽的影响  

Influence of Irbesartan on Heart Function and Sersum Brain Natriuretic Peptide in Patients with Chronic Heart Failure

作　　者：李暾[1] 唐力[1] 唐成玥 

机构地区：[1]四川省双流县第一人民医院心内科,610200

出　　处：《医学理论与实践》2011年第12期1378-1379,1389,共3页The Journal of Medical Theory and Practice

摘　　要：目的：探讨厄贝沙坦对老年慢性充血性心衰患者心功能及脑钠肽的影响。方法：选择100例心功能Ⅰ~Ⅳ级的慢性充血性心力衰竭（CHF）患者,随机分为两组：对照组50例常规抗心衰治疗（应用强心剂、利尿剂、β受体阻滞剂等）,治疗组50例在常规抗心衰基础上加用厄贝沙坦,观察两组治疗前、后心率、左室收缩功能及血浆脑钠肽（BNP）变化。结果：加用厄贝沙坦患者心率明显减慢,血压降低,左室舒张末期内径缩短,左室射血分数提高,BNP明显降低。结论：厄贝沙坦结合常规抗心衰治疗能够有效抑制慢性心力衰竭患者神经内分泌的过度激活,逆转心室重构,改善心功能,疗效优于单纯常规药物治疗,而动态监测患者血浆BNP水平可以帮助了解治疗效果及判断预后。Objective：To study of irbesartan in elderly patients with cardiac function in patients with chronic congestive heart failure and effects of brain natriuretic peptide.Methods：100 cases of cardiac function with chronic congestive heart failure（CHF）were randomly divided into two groups：the control group of 50 cases of conventional heart failure therapy（applied tonic,diuretic,beta blockers and so on）,the treatment group of 50 cases in a regular heart failure based on the additional use of irbesartan.Two groups of heart rate,before and after treatment of left ventricular systolic dysfunction and brain natriuretic peptide（BNP）were observed.Results：Irbesartan increased heart rate significantly,lowered blood pressure,reduced left ventricular end-diastolic diameter,increasing left ventricular ejection fraction,BNP significantly reduced.Conclusion：Irbesartan and conventional heart failure therapy in patients with chronic heart failure can inhibit excessive activation of neuroendocrine,reverse ventricular remodeling and improve heart function,and general effect is better than simple drug therapy,and dynamic monitoring of patients with plasma BNP concentration effects can help you understand treatment and prognosis

关 键 词：脑钠肽 厄贝沙坦 心力衰竭 

分 类 号：R541.61[医药卫生—心血管疾病]