宫颈病变中凋亡调控因子Bcl-2、Survivin及Fas的表达与意义  

Significance and Expression of Bcl-2、Survivin、Fas in Carcinogenesis of the Cervix

作　　者：杨峥莉[1] 赵扬[1] 刘荣霞[1] 张霞[1] 

机构地区：[1]河北省石家庄市第四医院妇产科,050011

出　　处：《医学理论与实践》2011年第12期1395-1397,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨Bcl-2、Survivin、Fas在宫颈癌发生、发展中的变化。方法:应用免疫组化SP法对42例宫颈上皮内瘤变(CIN)Ⅰ、38例CINⅡ、45例CINⅢ及40例浸润性宫颈鳞癌(ISCC)和30例正常宫颈组织的石蜡标本进行Bcl-2、Survivin、Fas的检测。结果:Bcl-2、Survivin在宫颈癌组织中的阳性率与CIN、正常宫颈组织有显著性差异(P<0.05),且在宫颈上皮癌变过程中CIN各组Bcl-2、Survivin表达呈逐级升高趋势,Fas在CIN及宫颈癌组织中的表达低于在正常组织中的表达,差异有显著性(P<0.05),且Survivin与Bcl-2、Fas有相关性。结论:Bcl-2、Survivin在宫颈癌和宫颈上皮内瘤样变中的表达水平增加,而Fas表达水平降低,提示Bcl-2、Survivin、Fas通过调控细胞凋亡参与了宫颈癌的发生和发展。Objective：To investigate the relation between apoptosis-related protein and the pathogenesis and progression of cervical cancer.Methods：125 cases of CIN,40 cases of invasive cervical cancer and 30 normal cervical tissues were investigated with immunohistochem technique.Results：There were significant differences in the positive rate of expression of Bcl-2,Survivin between cervical cancer,CIN and normal cervix（P0.05）.These differences became more conspicuous with advancement of pathological grouping.The positive expression rate of Fas in cervical cancer was significantly lower than that in normal tissues（P0.05）.Conclusion：Expression levels of Bcl-2 and Survivin are increased while expression level of Fas is decreased in cervical carcinomas and CIN.All of Bcl-2、Survivin and Fas may take part in the pathogenesis and development of cervical carcinoma.

关 键 词：CIN 宫颈癌 BCL-2蛋白 SURVIVIN蛋白 FAS蛋白 

分 类 号：R711.74[医药卫生—妇产科学]