妊娠期和哺乳期暴露于大气颗粒物对仔鼠中枢神经系统的影响  

Effects of Maternal Exposure to Atmospheric Particulates during Pregnancy and Lactation Period on Central Nervous System of Filial Generation among Rats

作　　者：李久存[1] 魏永杰[2] 陈田[1] 钱琴[1] 郭建[1] 宋艳双[1] 胡洁琼[1] 贾光[1] 

机构地区：[1]北京大学公共卫生学院,北京100191 [2]北京大学环境科学与化学工程学院,北京100191

出　　处：《环境与健康杂志》2011年第5期377-379,共3页Journal of Environment and Health

基　　金：国家重点基础研究发展("973")计划(2011CB933402)

摘　　要：目的研究母鼠在孕期及子代哺乳期暴露于大气颗粒物对仔鼠学习记忆能力以及海马单胺类神经递质含量的影响。方法选择健康成年妊娠0 d(见栓当天)SD大鼠,于2009年12月28日—2010年2月7日,采用平行的两个暴露箱,将妊娠期和哺乳期的暴露组孕鼠暴露于室外大气,对照组孕鼠暴露于经过滤装置滤除颗粒物后的大气;对其3周龄仔鼠用Morris水迷宫检测学习记忆能力,并检测仔鼠海马组织单胺类神经递质含量。结果暴露组仔鼠寻找平台潜伏期时间长于对照组(P<0.001)。暴露组仔鼠海马组织去甲肾上腺素(NE)和5-羟色胺(5-HT)含量均低于对照组(P<0.05),雄性仔鼠海马组织多巴胺(DA)含量低于对照组(P<0.05)。结论在妊娠期和哺乳期暴露于大气颗粒物会对仔鼠的中枢神经系统造成影响。Objective To study the effects on learning and memory ability and the content changes of monoamine neurotransmitter in hippocampus of filial generation when maternal rats exposed to atmospheric particulates during pregnancy and lactation period. Methods During Dec. 28th, 2009 to Feb. 7th, 2010, the experimental group was exposed to actual atmosphere in some area of Beijing in pregnancy and lactation period, while the control group exposed to atmosphere filtered without particulates. For the three weeks old young rats, the learning and memory ability were examined by using Morris water maze, while the content changes of monoamine neurotransmitter in hippocampus of neonatal mice were determined. Results In the place navigation period, the potential time finding flat incubation for offsprings in exposed group was significantly longer than that in the control group; in the spatial probe test period, the time of crossing the quadrant with flat and the traversing time decreased in exposed group. The contents of norepinephrine （NE） and 5-hydroxytryptamine（5-HT） in hippocampus of exposed rats were significantly increased, while dopamine （DA） was decreased but only with statistical significance in male rats. Conclusion Exposure to ambient atmospheric particulates in pregnancy and lactation periods can affect the central nervous system function of filial generation rats.

关 键 词：大气颗粒物 暴露 神经递质 学习记忆 

分 类 号：R994.6[医药卫生—毒理学]