不同清洁肠道药物降低肝癌术后高胆红素血症发生率的临床研究  

Effect of intestinal lavage with different drugs on the incidence of postoperative hyperbilirubinemia in patients with hepatectomy

作　　者：游雪梅[1] 莫新少[1] 詹爱丁[1] 钟丽[1] 陈似霞[1] 黎乐群[1] 

机构地区：[1]广西医科大学第一附属医院肝胆外科,南宁市530021

出　　处：《中华护理杂志》2011年第7期646-648,共3页Chinese Journal of Nursing

基　　金：广西自然科学基金项目(编号:0991143)

摘　　要：目的探讨可降低原发性肝癌术后高胆红素血症发生率的术前清洁肠道药物。方法将240例原发性肝癌患者随机分为A、B、C、D 4组,每组60例,分别采用25%硫酸镁(A组)、磷酸钠盐口服溶液(B组)、聚乙二醇电解质散(C组)、乳果糖口服溶液(D组)作为口服清洁肠道药物,于术后第1、3日检测血清胆红素值,比较各组高胆红素血症的发生率。结果使用4种药物的肠道清洁程度和术后肠功能恢复时间的差异无统计学意义(P>0.05);A组、C组高胆红素血症发生率显著低于B组、D组,差异有统计学意义(P<0.001);C组药物口感、接受度明显优于A组(P<0.05)。结论术前应用硫酸镁和聚乙二醇电解质散清洁肠道均可降低原发性肝癌术后高胆红素血症的发生率,聚乙二醇电解质散的口感和患者的接受度优于硫酸镁。Objective To explore the best intestinal lavage drug which can reduce the incidence of postoperative hyperbilirubinemia for patients with hepatectomy.Methods A total of 240 patients with primary liver cancer were randomly divided into four groups.Twenty-five percent magnesium sulfate,sodium phosphate,polyethylene glycol-electrolyte lavage solution（PEG-ELS） and lactulose oral solution were used as intestinal lavage drugs in group A,B,C,D,respectively.The levels of serum bilirubin at the first day and the third day after operation were tested.Results There was no significant difference on the cleansing effectiveness and duration of postoperative intestinal function recovery among the four groups（P0.05）.However,the incidences of postoperative hyperbilirubinemia in group A and group C were significantly lower than group B and group D（P0.001）.The taste and acceptability of PEG-ELS in group C was better than twenty-five percent magnesium sulfate in group A（P0.05）.Conclusion The incidence of postoperative hyperbilirubinemia is lower with the usage of twenty-five percent magnesium sulfate and PEG-ELS preoperatively.In terms of the taste and acceptability,PEG-ELS is better than twenty-five percent magnesium sulfate.

关 键 词：肝肿瘤 高胆红素血症 胆红素 投药 口服 肠道准备 

分 类 号：R473.73[医药卫生—护理学]