强的松联合来氟米特治疗紫癜性肾炎  

Treatment with prednisone and leflunomide in Henoch-Schonlein purpura nephritis

作　　者：刘高伦[1] 

机构地区：[1]攀枝花市中心医院肾内科,四川攀枝花617067

出　　处：《四川医学》2011年第6期876-877,共2页Sichuan Medical Journal

摘　　要：目的观察强的松联合来氟米特治疗过敏性紫癜性肾炎的疗效及安全性。方法对32例过敏性紫癜性肾炎患者,给予强的松联合来氟米特治疗24周,观察指标为皮疹、血常规、尿常规、24h尿蛋白定量、肝功能、肾功、电解质以及药物的不良反应。结果治疗12周后皮疹、血尿、蛋白尿完全缓解12例(37.5%),部分缓解16例(50%),总有效率87.5%;治疗24周后皮疹、血尿、蛋白尿完全缓解16例(50.0%),部分缓解13例(40.6%),总有效率90.6%;治疗过程中未观察到严重药物不良反应。结论强的松联合来氟米特治疗紫癜性肾炎疗效确切,不良反应小,但病情完全缓解可能需要较长疗程。Objective To evaluate the efficacy and safety of treatment with prednisone and leflunomide in Henoch-Schonlein purpura nephritis（HSPN）.Methods32 HSPN patients were treated with prednisone and lefl unomide for 24 weeks.Skin rashes,blood and urine routine,urine protein,blood biochemistry,and side effects were observed.Results12 patients achieved complete remission（37.5%）for skin rashes,hematuria,proteinuria,and 16 patients achieved partial remission（50%）after treatment for 12 weeks.The total efficacy of therapy was 87.5%.After treatment for 24 weeks,25 patients achieved complete remission（78.1%）and 5 patients achieved partial remission（15.6%）,with the total efficacy of 93.7%.No severe side effect occurred.ConclusionTreatment with prednisone and leflunomide is efficient and safe in HSPN patients.But a prolonged therapeutic period may be required.

关 键 词：来氟米特 紫癜性肾炎 疗效 不良反应 

分 类 号：R692.34[医药卫生—泌尿科学]