微创碎吸术手术时机对高血压脑出血血肿引流物中超氧化物歧化酶和丙二醛的影响  

Effects of operation timing of minimally invasive surgery on superoxide dismutase and malondialdehyde in hematoma drainage of hypertensive intracerebral hemorrhage

作　　者：石滴坚[1] 程泽沛[1] 

机构地区：[1]重庆市第三人民医院神经外科,400014

出　　处：《重庆医学》2011年第16期1574-1576,共3页Chongqing medicine

摘　　要：目的观察微创碎吸术手术时机对高血压脑出血血肿引流物中超氧化物歧化酶和丙二醛水平的影响。方法将80例高血压脑出血患者按手术时机分为A组(<6 h,45例)和B组(6～24 h,35例),用黄嘌呤氧化酶法监测血肿引流物中超氧化物歧化酶及丙二醛的动态变化。结果 A组与B组比较,A组在各时间点检测血肿引流物超氧化物歧化酶质量浓度较高(P<0.05),而丙二醛质量浓度较低(P<0.05)。结论超早期手术可能通过提高高血压脑出血血肿引流物中超氧化物歧化酶水平、降低丙二醛水平而增强自由基清除作用,改善患者预后。Objective To observe the effects of operation timing of minimally invasive surgery on levels of superoxide dismutase（SOD） and malondialdehyde（MDA） in hematoma drainage of hypertensive intracerebral hemorrhage.Methods 80 patients with hypertensive intracerebral hemorrhage（HIH） were divided into Group A（6 h,n=45） and Group B（6-24 h,n=35） according to the operation timing.Dynamic changes of SOD and MDA in hematoma drainage were monitored by xanthinoxidase method.Results Detection at different time points,mass concentrations of SOD in hematoma drainage in Group A were higher than those in Group B（P0.05）,whereas mass concentrations of MDA in Group A were lower than those in Group B（P0.05）.Conclusion Ultra-early operation can enhance activity of scavenging free radical to improve prognosis of patients probably via increasing the level of SOD and decreasing that of MDA in hematoma drainge of intracerebral hemorrhage.

关 键 词：颅内出血 高血压性 外科手术 微创性 超氧化物歧化酶 丙二醛 手术时机 

分 类 号：R651.1[医药卫生—外科学]