两种不同给药方式对晚期非小细胞肺癌紫杉醇脂质体化疗的影响  

EFFECTS OF DIFFERENT DELIVERY WAYS OF PACLITAXEL LIPOSOME ON THE CHEMOTHERAPY FOR ADVANCED NON SMALL CELL LUNG CARCINOMA

作　　者：黄勇[1] 崔社怀 

机构地区：[1]重庆市中山医院呼吸内科,重庆400013 [2]第三军医大学第三附属医院呼吸内科

出　　处：《现代预防医学》2011年第13期2599-2601,共3页Modern Preventive Medicine

摘　　要：[目的]明确支气管动脉灌注和常规静脉滴注两种不同给药方式对晚期非小细胞肺癌紫杉醇脂质体化疗的影响。[方法]紫杉醇脂质体联合奈达铂,分别通过外周静脉滴注和支气管动脉灌注两种方式应用于共32例晚期非小细胞肺癌患者,比较治疗有效率及不良反应发生率。[结果]与静脉给药组相比,支气管动脉灌注组实体瘤总有效率明显增高,且骨髓抑制、神经毒性及关节肌肉痛等药物毒性反应明显减少,患者更易耐受。[结论]紫杉醇脂质体通过支气管动脉灌注方式应用于晚期非小细胞肺癌患者的化疗,不仅可以明显减少药物的毒性反应,还能够提高临床疗效。[Objective]To identify the influences of two delivery ways,bronchial arterial infusion and intravenously guttae,of paclitaxel liposome on the chemotherapy for advanced non small cell lung carcinoma.[Methods]Total 32 patients with advanced non small cell lung carcinoma were treated with paclitaxel liposome and nedaplatin through bronchial arterial infusion or peripheral vein instillation respectively.The ratios of treatment response and adverse reaction were compared.[Results]Compared with intravenously guttae groups,the overall remission rate on solid tumor increased obviously and incidence rate of bone marrow depression,neurotoxicity,arthralgia and myalgia decreased significantly.So the patients were more easily to tolerate.[Conclusion]For the patients with advanced non small cell lung carcinoma,the chemotherapy with paclitaxel liposome through bronchial arterial infusion would decrease drug toxic reactions and elevate clinic curative effects obviously.

关 键 词：紫杉醇脂质体 晚期非小细胞肺癌 支气管动脉灌注化疗 

分 类 号：R734.2[医药卫生—肿瘤]