基于熵权的等效数值法在促透剂促透效果综合评价中的运用  

Usage of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers

作　　者：李志平[1] 林燕群[2] 王晖[2] 梁庆[1] 

机构地区：[1]广东省皮肤性病防治中心药剂科 [2]广东药学院中药药理学教研室

出　　处：《中国临床药理学与治疗学》2011年第4期417-422,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：广东省科技计划项目(2007A060305006);广东药学院中青年骨干教师资助项目

摘　　要：目的:探讨基于熵权的等效数值法在促透剂促透效果综合评价中的运用。方法:以扑热息痛为模型药物,利用离体透皮吸收装置,研究氮酮、薄荷醇、樟脑、油酸、丁香油、荆芥油、藿香油促透剂在离体兔背部皮肤上的透皮行为,计算渗透系数、稳态流量、滞后时间、增渗倍数,运用基于熵权的等效数值法对促透效果进行综合评价。结果:2%丁香和2%樟脑对扑热息痛的促透效果最好,1%氮酮、2%荆芥油、2%薄荷醇、2%油酸次之,2%广藿香最差。结论:基于熵权的等效数值评价法可客观地、公正地评价促透剂的促透效果。AIM： To investigate the use of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers. METHODS： Using paracetamol as model drug,the promoting effects of azone,menthol,camphor,oleic acid,clove oil,nepeta oil,patchouli oil were detected by transdermal absorption experimentation in rabbit skin in vitro,indexes such as cumulative permeation quantity,penetrating rates,enhancement ratio and lag time were calculated,finally the equivalent numerical method based on entropy weight was used to evaluate the promoting effects of those transdermal enhancers.RESULTS：The promoting effect of 2% camphor and 2% cloves promoted paracetamol was best,1% Azone,2% nepeta oil,2% menthol,2% oleic acid in sequence,2% patchouli oil was worst.CONCLUSION： The equivalent numerical method based on entropy weight could evaluate the promoting effect of transdermal enhancers objectively and fairly.

关 键 词：熵权 等效数值法 促透剂 促透效果 

分 类 号：R96[医药卫生—药理学]