特发性血小板减少性紫癜与巨细胞病毒、EB病毒感染相关性  

Correlation of Idiopathic Thrombocytopenic Purpura and Cytomegalovirus,EB Virus Infection

作　　者：蒋春英[1] 高卫英[1] 张春雨[1] 刘远英[1] 李亚杰[1] 

机构地区：[1]大庆市人民医院儿科,黑龙江大庆163316

出　　处：《现代生物医学进展》2011年第12期2292-2294,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨小儿特发性血小板减少性紫癜(ITP)与巨细胞病毒、EB病毒感染的关系。方法:实验组:48例确诊断为ITP患儿,对照组:44例同期呼吸道感染患儿,应用酶联免疫吸附法(ELISA)对两组小儿外周血进行巨细胞病毒IgM抗体(HCMV-IgM)、EB病毒感染IgM抗体(EB-IgM)检测。结果:48例ITP患儿中HCMV-IgM抗体阳性者20例,阳性率为41.67%,明显高于对照组,两组之间差异有显著性(P<0.01);EBV-IgM抗体阳性者14例,阳性率为29.17%,明显高于正常对照组,两组之间差异有显著性(P<0.05)。结论:1、巨细胞病毒感染是引起特发性血小板减少性紫癜的重要原因之一,且通过临床观察巨细胞病毒感染引起的ITP患儿病情重,病程长,治疗时间长,转为慢性ITP的可能性大;2、EB病毒感染可能是引起特发性血小板减少性紫癜的原因之一,并且EB病毒感染引起的特发性血小板减少性紫癜病情也偏重。Objective：To investigate children with idiopathic thrombocytopenic purpura（ITP） and CMV,EB virus infection.Methods：Experimental group：48 patients diagnosed with ITP in children is indeed the control group：44 cases of children with respiratory tract infection over the same period,enzyme-linked immunosorbent assay（ELISA） in peripheral blood of two groups of children with IgM antibodies to cytomegalovirus（HCMV-IgM）,EB virus IgM antibody（EB-IgM） detection.Results：48 cases of ITP children with positive HCMV-IgM antibodies in 20 cases,the positive rate was 41.67%,significantly higher,the difference between the two groups was significant（P 0.01）;EBV-IgM antibodies in 14 cases,the positive rate was 29.17%,significantly higher than the control group,the difference between the two groups was significant（P 0.05）.Conclusion：1,CMV infection is the cause of idiopathic thrombocytopenic purpura is one of the important reasons,and through clinical observation of cytomegalovirus infection in ITP patients with severe illness,longer duration,treatment for a long time to chronic ITP the possibility of large;2,EB virus infection may be caused by idiopathic thrombocytopenic purpura one of the reasons,and EB virus infection with idiopathic thrombocytopenic purpura is also biased towards the disease.

关 键 词：血小板减少性紫癜 特发性 巨细胞病毒 EB病毒 ELISA 

分 类 号：R558[医药卫生—血液循环系统疾病] R373[医药卫生—内科学]