ABO血型不合异基因造血干细胞移植对红系造血恢复的影响  

Effect of ABO-incompatible Allogeneic Stem Cell Transplantation on Erythroid Lineage Hematopoiesis

作　　者：蔡雪娇[1] 洪俊英[1] 陈怡[2] 俞康[2] 

机构地区：[1]温州医学院附属第一医院输血科,浙江温州325000 [2]温州医学院附属第一医院血液内科,浙江温州325000

出　　处：《中国实验血液学杂志》2011年第3期801-804,共4页Journal of Experimental Hematology

摘　　要：本研究探讨ABO血型不合异基因造血干细胞移植对红系造血的影响。对16例ABO血型不合的造血干移植患者的ABO血型,IgM和IgG抗体进行监测。结果显示,16例ABO血型不合的造血干细胞移植患者均恢复造血功能,与ABO血型相合组比较,ABO血型不合组在粒细胞植活时间、血小板植活时间无差异,但红系重建时间明显延长;ABO主侧不合与双侧不合受者抗供者凝集素消失时间与红系恢复时间有相关性。结论 :ABO血型不合的异基因造血干细胞移植会导致红系造血迟缓。移植前用供型血浆置换法或输注供者红细胞来中和受者体内抗供者红细胞的凝集素能缩短红细胞植入时间,减少红细胞的输注。This study was purposed to investigate the effect of ABO-incompatible allogeneic hematopoietic stem cell transplantation（allo-HSCT） on erythroid lineage hematopoiesis. The changes of ABO group, IgM and IgG antibody in 16 patients reveiced ABO-incompatible allo-HSCT were detected. The results showed that ABO-incompatible allo-HSCT were successfully engrafted in 16 patients, and there was no difference in reconstitution of platelets and neutrophils between ABO-incompatible and ABO-compatible transplantation （p 〉 0.05 ）. The time of erythroid lineage reconstitution was prolonged（p 〈 0.05 ）, the disappearance time of isoagglutinins against donor-type RBC in major and bidirectional ABO-incompatible recepients was correlated with the time of erythroid lineage reconstitution. It is concluded that ABO-incompatible allo-HSCT may lead to prolong recovery of erythroid lineage hematopoiesis. Before transplantation, the removal of anti-donor isoagglutinins by plasmapheresis or transfusion of donor＇s erythrocytes for neutralizing the isoagglutinins against donor＇s erythrocytes in the recepients may facilitate RBC engraftment and reduce erythrocyte transfusion.

关 键 词：ABO血型不合 干细胞移植 

分 类 号：R457.7[医药卫生—治疗学] R457.11[医药卫生—临床医学]