T否决细胞促进造血干细胞植入的研究  

Veto T Cells Enhance Engraftment Allogeneic Hematopoietic Stem Cells——Review

作　　者：李凤[1,2] 段连宁[1] 纪树荃[1] 

机构地区：[1]空军总医院血液科,北京100142 [2]第四军医大学研究生队,陕西西安710032

出　　处：《中国实验血液学杂志》2011年第3期824-827,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金项目资助;编号30873014

摘　　要：否决效应是一种能特异性抑制识别否决细胞自身表面抗原的细胞毒性T细胞前体细胞(CTL-p)的攻击,而CTL-p对识别第三方抗原无抑制作用。具有否决效应的细胞称为否决细胞。细胞毒性T淋巴细胞(cytotoxic Tlymphocyte,CD8+CTL)是现知否决活性最强的细胞。在异基因造血干细胞移植中,输注供者源的CD8+CTL否决细胞清除宿主同种异体反应细胞可以促进供者干细胞的植入。本文就近年来关于CD8+CTL否决效应的机制、GVH效应、抗肿瘤效应、活体内的应用及与药物和细胞之间的协同作用的研究进展做一综述。Veto activity was defined as the capacity of specifically downregulatng cytotoxic T-precursor cell （CTL- p） directed against antigens of the veto cells themselves but not against third-party antigens. Many studies have shown that the most potent veto cells are CD8 ＋ cytotoxic T lymphocytes （ CD8＋ CTLs）. Effectively, CD8 ＋ CTLs of donor origin can facilitate engraftment of donor＇s stem cells by eliminating host-alloreactive T lymphocytes. In this article, effect mechanisms, depletion of GVH ex vivo, application in vivo, synergistic enhancement with rapamycin and regulatory T cells, and anti-tumor effect in the hematopoietic stem cell transplantation are summarized.

关 键 词：否决细胞 造血干细胞移植 免疫耐受 

分 类 号：R457.7[医药卫生—治疗学]