药物相关酶的表达或活性对结直肠癌化疗的预测作用  

The predictive role of expression or activity of drug-related enzymes in chemotherapy for colorectal cancer

作　　者：赵静[1] 张文[1] 

机构地区：[1]复旦大学附属肿瘤医院肿瘤内科,复旦大学上海医学院肿瘤学系,上海200032

出　　处：《肿瘤》2011年第5期465-468,共4页Tumor

摘　　要：结直肠癌是常见的恶性肿瘤之一,随着新药物的应用,使其化疗效果取得了较大的进步,但是耐药仍然是结直肠癌患者化疗过程中面临的主要问题。研究显示,不同患者的肿瘤组织中药物代谢相关酶的表达及活性也不尽相同,这可能是影响化疗疗效和预后的关键因素之一。本文就此作一综述,探讨药物相关酶对结直肠癌化疗疗效和预后的预测作用。Colorectal cancer is one of the most malignant tumors.Recently,with the approval of multiple new agents,significant progress has been made in chemotherapy for colorectal cancer.However,resistance to chemotherapy remains a major obstacle in effective treatment for colorectal cancer.Drug-related enzymes differ in different patients,which may be a key factor affecting the efficacy and prognosis of chemotherapy.This article reviews several drug-related enzymes,in order to explore their predictive roles in prediction of efficacy and prognosis of chemotherapy for colorectal cancer.

关 键 词：结肠直肠肿瘤 抗肿瘤联合化疗方案 遗传药理学 预测 

分 类 号：R733.7[医药卫生—肿瘤]