黑龙江省3866名健康儿童静脉血细胞参数参考范围调查  

Investigation of venous blood cells from 3866 children in Heilongjiang Province to get reference ranges for clinical usages

作　　者：杜娟[1] 吴卫[1] 邱玲[1] 徐涛[2] 黄大伟[1] 辛丽亚[1] 陈倩[1] 程歆琦[1] 王庚[1] 韩少梅[2] 朱广瑾[2] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院检验科,北京100730 [2]中国医学科学院北京协和医学院基础医学研究所,北京100005

出　　处：《基础医学与临床》2011年第7期756-761,共6页Basic and Clinical Medicine

基　　金：国家科技部科技基础性工作专项重点项目(2006FY110300)

摘　　要：目的调查分析黑龙江省健康儿童静脉全血细胞8个参数的水平,建立各参数的儿童参考范围。方法 随机抽取黑龙江省部分地区8～16岁健康儿童3 866人(男性1 837人,女性2 029人),采集受试者清晨空腹静脉血,用Sysmex XT-1800i全血细胞分析仪进行检测。采用SPSS 15.0软件分析比较各参数在民族、地区及年龄间的差异。结果 黑龙江省健康儿童静脉血细胞参数均值(参考范围)中白细胞计数为6.9(3.9～9.9)×109/L,红细胞计数男性为5.0(4.2～5.8)×1012/L,女性为4.6(4.0～5.2)×1012/L,血红蛋白浓度男性为146(124～168)g/L,女性为135(117～153)g/L,血细胞比容男性为43.9%(37.5%～50.5%),女性为41.2%(36.4%～46.0%),红细胞平均体积为88(80～96)fl,红细胞平均血红蛋白含量为29(25～33)pg,红细胞平均血红蛋白浓度为329(311～347)g/L,血小板计数为277(161～393)×109/L。汉族、朝鲜族健康儿童的WBC、HGB、MCH、MCHC及PLT5项参数存在显著差异(P<0.05);黑龙江省各地区间血细胞各参数均存在不同程度差异(P<0.05)。年龄组间比较,除WBC外,余各参数在不同年龄组间均存在不同程度的差异(P<0.05),其中RBC、HGB、HCT、MCV及MCH与年龄呈正相关,MCHC、PLT与年龄呈负相关。结论 初步建立了黑龙江省健康儿童静脉血细胞分析参数的参考范围,发现了汉族与朝鲜族以及黑龙江不同地区间儿童静脉血细胞分析参数的差异。Objective To establish all hepatocytes related reference ranges for normal children by investigating 8 parameters referred to children＇s venous whole blood in Heilongjiang Province.Methods Fasting venous blood samples of 3 866 healthy children aged 8 to 16（1 837 male and 2 029 famale）were taken into EDTA-K2 anticoagulation tube,and the related reference values were measured by Sysmex XT-1800i hematoanalyzer.Software SPSS 15.0 was used for statistical analysis to descript the deviations between ages、races and regions.Results The means（reference ranges） of venous blood of 3866 health children in the Heilongjiang Province were as follows： White blood cells count to 6.9（3.9～9.9）×109/L,Red blood cells count to 5.0（4.2～5.8）×1012/L for male and 4.6（4.0～5.2）×1012/L for female,the hemoglobin concentration was 146（124～168）g/L for male and 135（117～153）g/L for female,the Hematocrit was 43.9%（37.5%～50.5%） for male and 41.2%（36.4%～46.0%） for female,the Mean corpuscular volume was 88（80～97）fl,the mean corpuscular hemoglobin was 29（25～33）pg,the mean corpuscular hemoglobin concentration was 329（311～347）g/L,the platelet count was 277（161～393）×109/L.Among health children,when compared with Korean ethnic minority group,all indexes like RBC、HCT、MCV and PDW of Han nationality did not show any differences with statistical significance.While there were remarkably differences on WBC、HGB、MCH、MCHC and PLT（P0.05）.Comparing between different ages and groups,all parameters except WBC presented with significant differences（P0.05）,positive correlation was found between RBC、HGB、HCT、MCV、MCH and age,negative correlation was found between MCHC、PLT and age.Conclusion Basic data bank for reference ranges of venous blood of healthy children in Heilongjiang Province has been initially established.And the differences are found among different age groups,nations and geographic regions of the children aged 8 to 16 is of great value in clinical p

关 键 词：健康儿童 汉族 朝鲜族 静脉血 血细胞参数 

分 类 号：R446.11[医药卫生—诊断学]