吡唑酸类化合物的合成研究  

Study on synthesis of pyrazole acids

作　　者：高宁[1] 王元元[1] 肖亚平[1] 

机构地区：[1]南京师范大学化学与材料科学学院,江苏南京210097

出　　处：《化学研究》2011年第3期40-43,共4页Chemical Research

摘　　要：通过探究吡唑酸的四种不同合成方法,筛选了适合于工业化生产的合成路线;并利用农药氯虫酰胺重要中间体——3-溴-1-(3-氯吡啶-2-基)-1H-吡唑-5-甲酸的合成进行了验证,产物结构经核磁共振谱(1H NMR)确认.The best route to the industrialized synthesis of pyrazole acids was screened by exploring four kinds of different synthetic methods of pyrazole acids.The route was verified by successful synthesis of 3-bromo-1-（3-chloro-2-pyridinyl）-1H-pyrazole-5-carboxylic acid,an important intermediate of pesticide chlorantraniliprole.The structure of the product was confirmed by means of nuclear magnetic resonance spectroscopy（1H NMR）.

关 键 词：吡唑酸 农药 中间体 工业化 合成 

分 类 号：O622.5[理学—有机化学]