急性脑梗死患者血清白介素-18水平与颈动脉斑块的关系  

Correlation of Carotid Artery Plaques and Serum Interleukin-18 Levels of Patients with Acute Cerebral Infarction

作　　者：李薇[1] 杨全玉[1] 李时光[1] 

机构地区：[1]郑州市第一人民医院神内一科,郑州450004

出　　处：《神经损伤与功能重建》2011年第3期184-186,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨急性脑梗死患者血清白介素-18(IL-18)水平的变化与颈动脉斑块的关系。方法:将121例急性脑梗死患者(梗死组)根据颈动脉超声结果分为无斑块亚组(37例)、稳定斑块亚组(41例)和不稳定斑块亚组(43例),抽取所有患者发病急性期(1 d)和恢复期(12 d)的空腹静脉血,采用双抗体夹心酶联免疫吸附法(ELISA)测定血清IL-18的水平,并与31名健康对照者(对照组)进行比较。结果:脑梗死急性期不稳定斑块亚组的IL-18水平明显高于稳定斑块亚组、无斑块亚组及对照组,稳定斑块亚组的IL-18水平明显高于无斑块亚组及对照组,无斑块亚组的IL-18水平明显高于对照组,差异均具有统计学意义(P<0.05)。脑梗死恢复期不稳定斑块亚组的IL-18水平明显高于稳定斑块、无斑块亚组及对照组,稳定斑块亚组的IL-18水平明显高于无斑块亚组及对照组,差异均有统计学意义(P<0.05),无斑块亚组与对照组差异无统计学意义。结论:急性脑梗死患者血清IL-18的水平与斑块形成及斑块的稳定性密切相关。Objective：To explore the relationship of carotid artery plaques and serum interleukin-18 levels in patients with acute cerebral infarction. Methods： Using carotid ultra-sonographic methods, 121 patients with acute cerebral infarction were divided into three subgroups, the subgroup no carotid plaques （NCP）（n= 37）, the Subgroup stable plaque（SP） （n= 41）, and the subgroup vulnerable plaques（VP）（n=43）. The Serum IL-18 levels of all patients with acute cerebral infarction and 31 healthy controls were measured by enzyme linked immunosorbent assay （ELISA） at days 1 and 12 after onset. Results：At day 1 and 12 after onset, the IL-18 levels of subgroup VP were significantly increased than other groups （P〈0.05）. However, the IL-18 levels in the subgroup SP were significantly higher than those in the subgroup NCP and control group （P〈0.05）. No difference was observed between the subgroup NCP and control group. Conclusion： The level of serum IL-18 in patients with acute cerebral infarction may be a valuable indicator for characteristics of carotid plaques.

关 键 词：急性脑梗死 白介素-18 颈动脉斑块 

分 类 号：R753.9[医药卫生—皮肤病学与性病学]