枸杞对耐力训练大鼠肝细胞超微结构及抗氧化能力的影响  

Effects of Lycium on Liver Cellular Ultrastructure and Antioxidant Activity of Rats under Tolerance Training

作　　者：季丽萍[1] 许继安[2] 郭成吉[1] 

机构地区：[1]徐州师范大学体育学院,徐州221116 [2]徐州师范大学管理学院,徐州221009

出　　处：《生物医学工程学杂志》2011年第3期501-505,共5页Journal of Biomedical Engineering

基　　金：江苏省高校自然科学基础研究项目资助(08KJB340001)

摘　　要：将64只8周龄雌性大鼠随机分为对照和药物两大组(共8小组),每小组8只,训练组和药物组分别进行为期5周的游泳运动和灌喂枸杞煎剂。5周后,观察不同状态下肝细胞超微结构的变化和肝脏超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量来探讨枸杞对大鼠的运动能力、自由基防御体系以及肝细胞超微结构的影响。结果显示,耐力训练可延长大鼠力竭性游泳时间;枸杞可使大鼠力竭性游泳时间进一步延长。枸杞组大鼠肝脏细胞超微结构均比相应对照组完整,损伤程度较轻。枸杞(LCM)使大鼠肝组织SOD活性升高,MDA含量降低,SOD/MDA比值显著升高。本研究表明枸杞和耐力训练可提高运动能力;枸杞有保肝作用。64 eight-week-old female rats were randomly divided into to 8 groups with four in medical treatment group and four in control group.The treatment groups were trained by progressive intensifying endurance swimming,and the medical-taken groups were fed with lycium for 5 weeks,and then the changes of the liver cellular free radical metabolism and ultrastructure were investigated.The effects of lycium and endurance training on liver cellular ultrastructure and free radical metabolism in rats were then explored.The results showed that exhaustive swimming time of rats could be extended by endurance training,and that exhaustive swimming time of rats could significantly be prolonged after taking lycium, and the ultrastructure of liver cell with taking lycium was more complete than that without taking lyceum.Lycium could cause significant increase of the activity of liver superoxide dismutase（SOD） and the ratio of SOD/MDA,and meanwhile cause decrease of the content of liver MDA.Conclusions can be drawn that lycium and endurance training can improve exercise capacity of rats,and lycium has certain protecting functions of the liver.

关 键 词：枸杞 运动大鼠 抗氧化 肝细胞超微结构 

分 类 号：R285.5[医药卫生—中药学] R87[医药卫生—中医学]