结缔组织病并间质性肺病患者血清IL-32、IL-12的临床意义  

Clinical Significance of IL-32 and IL-12 serum levels in interstitial lung disease with connective tissue disease

作　　者：夏玲[1] 张继先[1] 杨炯[2] 

机构地区：[1]湖北省新华医院呼吸科,湖北武汉430015 [2]武汉大学中南医院呼吸科,湖北武汉430071

出　　处：《临床肺科杂志》2011年第7期1026-1029,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨结缔组织病并间质性肺病患者(CTD-ILD)与非结缔组织病引起的间质性肺疾病(IFP+NSIP)患者及正常人外周血血清中白细胞介素32(IL-32)和白细胞介素12(IL-12)水平的差异及意义。方法选择8例结缔组织病并间质性肺病患者(CTD-ILD),其中包括6例类风湿性关节炎(RA)并间质性肺病患者(RA-ILD组),2例硬皮病(SSA)并间质性肺病患者(SSA-LD组);10例非结缔组织病引起的间质性肺疾病(IPF+NSIP),其中包括8例特发性肺间质纤维化患者(IPF组),2例非特异性间质性肺炎患者(NSIP组);选择10例正常人(control组),采用特异的酶联免疫吸附法测定外周血血清中IL-32、IL-12的水平。结果 CTD-ILD组外周血血清中IL-32、IL-12水平明显高于对照组,差异有统计学意义(P<0.05);CTD-ILD组外周血血清中IL-32、IL-12水平明显高于IPF+NSIP组,差异有统计学意义(P<0.05)。Objective To assess IL-12 and IL-32 serum levels in peripheral blood of patients who sufferd interstitial lung disease with or without connective tissue disease.Methods 8 patients with CTD-ILD, 10 patients with IPF or NSIP, 10 healthy controls were included in this study. Serumconcentrations of IL-32 and IL-12 were measured by ELISA.Results IL-32 and IL-12 serumlevels were significantly higher in the patients of CTD-ILD than those in the control group （P〈0.05）. IL-32 and IL-12 serum levels were significantly higher in the patients of CTD-ILD than those in the IPF＋NSIP group （P〈0.05）.Conclusion The difference in IL-32 and IL-12 levels may help us to to make a right diagnosis about CTD-ILD.

关 键 词：IL-32 IL-12 血清 结缔组织病 间质性肺疾病 

分 类 号：R563.9[医药卫生—呼吸系统]