地塞米松联合异烟肼胸腔内注射治疗结核性胸膜炎的疗效观察  

Clinical study of dexamethasone combined with isoniazid in the treatment of tuberculous pleurisy by chest injection

作　　者：汪慧兰[1] 

机构地区：[1]武汉市黄陂区人民医院感染科,湖北武汉430300

出　　处：《临床肺科杂志》2011年第7期1057-1058,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨地塞米松联合异烟肼胸腔内注射治疗结核性胸膜炎的临床疗效。方法 66例结核性胸膜炎患者随机分为两组,对照组(34例)为常规口服抗结核药物及胸腔穿刺抽液治疗,治疗组(32例)在对照组治疗基础上,胸腔抽液后注入异烟肼0.2 g,地塞米松5 mg。两组疗程均为2周。观察两组患者治疗后胸水吸收及胸膜肥厚粘连情况。结果治疗组治疗总有效率(90.6%)明显优于对照组治疗总有效率(79.4%)(P<0.05);治疗组胸膜肥厚粘连发生率(9.4%)也明显低于对照组(20.6%)(P<0.05)。结论地塞米松联合异烟肼胸腔内注射治疗结核性胸膜炎可快速消除胸水及减轻胸膜的肥厚粘连情况。Objective To investigate the clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous pleurisy by chest injection.Methods 66 cases of tuberculous pleurisy were randomly divided into two groups.The patients in control group（34 cases） was treated by conventional oral anti-TB drugs and pleural puncture fluid therapy,while those in the treatment group（32 cases） were treated by pumping the chest after the injection of liquid isoniazid 0.2 g,dexamethasone 5mg based on control group.The treatment course for both was two weeks.The situation of pleural effusion,pleural thickening and adhesions absorption were observed after treatment.Results The total effective rate of treatment group（90.6%） was significantly better than the total effective rate of the control group（79.4%）（P〈0.05）;the incidence of pleural thickening and adhesion of treatment group（9.4%） was significantly lower than the control group（20.6%）（P〈0.05）.Conclusion Dexamethasone combined with isoniazid in the treatment of tuberculous pleurisy by chest could quickly eliminate pleural effusion and reduce the thickening pleural adhesions.

关 键 词：地塞米松 异烟肼 结核性胸膜炎 

分 类 号：R521.7[医药卫生—内科学]