替罗非班治疗不稳定型心绞痛的临床观察  

Effect of Tirofiban in Treating Unstable Angina

作　　者：祝志云[1] 王梦洪[2] 段文峰[1] 

机构地区：[1]南昌大学研究生院医学部,2008级南昌330006 [2]南昌大学第一附属医院心内科,南昌330006

出　　处：《南昌大学学报（医学版）》2011年第2期55-57,共3页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨替罗非班治疗不稳定型心绞痛的临床效果和安全性。方法将不稳定型心绞痛患者64例按随机数字表法分为治疗组和对照组,每组32例。对照组给予氯吡格雷、阿司匹林和低分子肝素等药物联合治疗;治疗组在对照组治疗的基础上加用替罗非班。观察2组患者住院2周内心肌梗死发生率、心绞痛发作次数、心电图改善情况和出血不良事件发生情况。结果与对照组相比,治疗组患者心肌梗死发生率、心绞痛发作次数比对照组显著减少(P<0.05);治疗组心电图明显改善,但2组差异无统计学意义(P>0.05);治疗期间2组患者出血不良事件发生率差异无统计学意义(P>0.05)。结论替罗非班治疗不稳定型心绞痛可有效地减少心肌梗死发生率、缓解心绞痛的症状及改善心电图,治疗期间无严重的出血倾向,临床应用安全、有效。Objective To study the clinical effect and safety of tirofiban in the treatment of unstable angina（UA）.Methods Sixty-four patients diagnosed with UA were randomly divided into two groups.Control group（32 patients） received clopidogrel,aspirin and low molecular weight heparin.On this biasis,treatment group（32 patients） was given additional tirofiban.The incidence of myocardial infraction,frequency of angina pectoi,changes in electrocardiogram（ECG） and adverse reactions were observed during two-week therapeutic course.Results Compared with control group,the incidence of myocardial infraction and the frequency of angina pectoris decreased in treatment group（P0.05）.Both groups showed an improvement in ECG after treatment.There were no significant differences in ECG and the incidence of adverse reactions between the two groups（P0.05）.Conclusion Tirofiban can effectively reduce myocardial infraction,relieve angina symptoms,improve ECG in treatment of UA with no obvious hemorrhagic tendency.

关 键 词：替罗非班 不稳定型心绞痛 疗效 安全性 

分 类 号：R541.4[医药卫生—心血管疾病]