血尿酸对早期糖尿病肾病预后影响的分析  

Serum uric acid level is a risk factor for the progress of diabetic nephropathy

作　　者：齐云秋[1] 秦贵军[1] 刘章锁[2] 王春燕[2] 

机构地区：[1]郑州大学第一附属医院内分泌科,450052 [2]肾内科,郑州大学第一附属医院450052

出　　处：《中华全科医师杂志》2011年第6期433-434,共2页Chinese Journal of General Practitioners

摘　　要：以306例早期糖尿病患者为研究对象,采用生存分析的方法 探讨血尿酸对早期糖尿病肾病患者预后的影响.结果 显示,随访结束时288例临床资料完整,高尿酸组64例,非高尿酸组224例,高尿酸组显性白蛋白尿和肾小球滤过率下降终点事件发生率显著高于非血尿酸组,分别为47.36%与30.29%和66.14%与37.72%（P〈0.05）,提示高尿酸血症是糖尿病肾病进展的危险因素.Total 306 patients with early stage diabetes were enrolled in the study, after follow-up for 67 ± 8 months, the data of 288 cases were analyzed with survival analysis method. At the end of study 64 out 288 patients had high serum uric acid and the remaining 224 had normal uric acid levels. The prevalence of dominant proteinuria and reduced GFR were significantly higher in patients with high serum uric acid than those with normal serum uric acid （47. 36% vs 30. 29% and 66. 14% vs 37.72%, respectively, both P 〈0. 05）. The results suggest that high level of serum uric acid is a risk factor for the progress of diabetic nephropathy.

关 键 词：尿酸 预后 

分 类 号：R587.2[医药卫生—内分泌]