超滤膜分离提纯苦楝素  

Separation and purification of toosendanin extraction solution by an ultrafiltration membrane

作　　者：王龙德[1] 崔鹏[2] 路绪旺[2] 佟玲[1] 姚路路[2] 

机构地区：[1]淮南师范学院化学与化工系,安徽淮南232001 [2]安徽省可控化学与材料化工重点实验室(合肥工业大学),安徽合肥230009

出　　处：《山东大学学报（工学版）》2011年第3期154-159,172,共7页Journal of Shandong University（Engineering Science）

基　　金：安徽省高等学校省级自然科学基金资助项目(KJ2009B264Z)

摘　　要：研究了微孔滤膜和超滤膜从苦楝树皮的微波提取液中膜分离提纯苦楝素的相关膜工艺条件及参数,并筛选出较为理想的聚砜超滤膜。研究结果表明,截留分子量为6 K的聚砜UEOS-503超滤膜分离提纯苦楝素的效果要优于截留分子量分别为10 K和20~50 K的聚砜USIC-503和UPIS-503。为提高苦楝素的纯度和苦楝素转移率,得出超滤膜分离提纯苦楝素优化工艺条件：料液质量浓度为0.369 mg/mL,料液温度35℃,膜操作压力差为0.10MPa,膜面流速6.17×10-4m/s,膜滤液pH=7.0。在优化条件下,苦楝素的转移率为92.8%,提取液中苦楝素的纯度由0.89%,提高到15.22%。Microfiltration and ultrafiltration membrane separation methods were studied for purifying toosendanin from crude extracts of the bark of azedarach by microwave-assisted extraction.The polysulfone ultrafiltration membranes UEOS-503,USIC-503 and UPIS-503 were studied for separating and purifying toosendanin.The results showed that polysulfone UEOS-503 ultrafiltrating membrane with retenting molecular weight 6 K was much better than USIC-503（10 K） and UPIS-503（20~50 K） in separating and purifying toosendanin.In order to improve the toosendanin purity and transfer rate,the optimal separating and purifying conditions were investigated and obtained as follows： the raw concentration of toosendanin was 0.369 mg/mL,the temperature was 35 ℃,the operating pressure of 0.10 MPa,the cross flow velocity was 6.17×10-4m/s,and the pH value was 7.0.Under the optimum conditions,the toosendanin transfer rate was 92.8%,and the purity of toosendanin increased from 0.89% to 15.22%.

关 键 词：苦楝 苦楝素 超滤膜 提纯 

分 类 号：O629.9[理学—有机化学]