吐纳麝香合成及工艺优化  

Synthesis and Process Optimization of Tonalide Musk

作　　者：吴秀芹[1] 邓瑞雪[1] 刘普[1] 尹卫平[1] 

机构地区：[1]河南科技大学化工与制药学院,河南洛阳471003

出　　处：《河南科技大学学报（自然科学版）》2011年第3期92-94,98,共4页Journal of Henan University of Science And Technology:Natural Science

基　　金：国家中小企业技术创新基金项目(10C26214104503)

摘　　要：通过改变催化剂的组成和反应时间(70 min),混合催化剂n(无水AlCl3)∶n(浓H2SO4)=10∶1,吐纳麝香中间体1,1,3,4,4,6-六甲基四氢化萘(HMT)的合成产率达到86%;产品通过用无水乙醇饱和溶液低温结晶法,取代了原合成单元操作中的减压精馏和重结晶操作,使吐纳麝香(AHMT)合成总产率达到80%。该技术过程简单,实施方便,有效地降低了产品吐纳麝香的生产成本,实现了对吐纳麝香的合成工艺优化。By changing the composition of catalyst for a benefited synthesis reaction of an intermediate of 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene(HMT),n(AlCl3)∶ n(H2SO4) =10∶1,with the reaction time 70 min,the yield of HMT was 86%.Tonalide Musk(AHMT) was purified by low temperature crystallization of saturating ethanol solution,which replaced the previously distillation and recrystallization operation.The total yield of perfume production was 80%.The synthestic technology of AHMT is optimized.

关 键 词：吐纳麝香 香料合成 反应机理 工艺优化 

分 类 号：TQ656.2[化学工程—精细化工]