IL-12家族细胞因子:肿瘤免疫治疗研究的热点分子  

IL-12 family cytokines:Hot key molecules in tumor immunotherapy

作　　者：单保恩[1] 

机构地区：[1]河北医科大学第四医院科研中心暨河北省肿瘤研究所,石家庄050011

出　　处：《中国肿瘤生物治疗杂志》2011年第3期239-243,共5页Chinese Journal of Cancer Biotherapy

基　　金：国家自然科学基金资助项目(No.30772752);国家"十一五"重大科技支撑计划资助项目(No.2006BAI02A07)~~

摘　　要：利用细胞因子提高宿主免疫能力、破坏肿瘤细胞的免疫逃逸功能是肿瘤生物治疗的重要策略。IL-12细胞因子家族是具有高度同源性的一类异源二聚体细胞因子,包括IL-12、IL-23、IL-27和IL-35,它们均由活化的抗原提呈细胞如巨噬细胞和树突状细胞产生,在辅助性T细胞分化过程中起重要作用。IL-12通过活化ATAT4信号转导途径产生IFNγ-促进细胞免疫反应;IL-27主要活化STAT1途径增强细胞和体液免疫反应;外源性IL-23可以产生抗肿瘤效应,而内源性IL-23通过活化STAT3诱导产生IL-17,从而促进肿瘤的发生和发展;IL-35可能是潜在的免疫抑制性细胞因子。总之,IL-12细胞因子家族成员在肿瘤免疫反应中各自发挥不同的作用,已成为肿瘤免疫治疗和研究的热点分子。Cytokines,which can improve the host immunity and hamper the immune escape of tumor cells,have become an important strategy for tumor biotherapy.Interleukin（IL）-12 cytokine family is composed of heterodimeric cytokines,including IL-12,IL-23,IL-27 and IL-35;they are produced by antigen-presenting cells such as macrophages and dendritic cells and play critical roles in the differentiation of helper T（Th） cells.IL-12 induces IFN-γ production through activating signal transducer and activator of transcription（STAT） 4 signaling pathway and enhances cellular immune response;IL-27 augments cellular and humoral immune responses through activating STAT1 pathway;exogenous IL-23 can produce anti-tumor effects,while endogenous IL-23 induces the production of IL-17 by activating STAT3,promoting development and progress of tumors;and IL-35 may be a potential immunosuppressive cytokine.In summary,IL-12 cytokine family plays distinct roles in anti-tumor immune responses and has become a focus of study in the research and immune therapy of tumors.

关 键 词：细胞因子 IL-12细胞因子家族 肿瘤生物治疗 白细胞介素 肿瘤免疫 

分 类 号：R392.1[医药卫生—免疫学] R730.5[医药卫生—基础医学]