HBV相关性肾炎的抗病毒治疗  

Antiviral therapy in patients with hepatitis B virus-associated glomerulonephritis

作　　者：熊清芳[1] 杨永峰[1] 

机构地区：[1]南京市第二医院肝病科,江苏省南京市210003

出　　处：《世界华人消化杂志》2011年第15期1620-1623,共4页World Chinese Journal of Digestology

摘　　要：乙型肝炎病毒相关性肾炎(hepatitis B virus associated glomerulon ephritis,HBV-GN)是HBV感染的表现之一.已有多种药物被用于治疗HBV-GN,但迄今为止尚无最佳的治疗方案.抗病毒(包括干扰素和核苷类似物)治疗HBV-GN能有效抑制HBV复制、缓解蛋白尿,且HBeAg的清除与蛋白尿的缓解密切相关,并能在一定程度上延缓肾功能恶化的发生,大多数患者耐受性好,而糖皮质激素治疗HBV-GN,其预后无明显改善.Hepatitis B virus-associated glomerulonephritis（HBV-GN）is a common clinical condition.Up to now,the optimal therapy is undefined although several approaches have been made.This paper reviews the efficacy and safety of antiviral therapy（including interferon and lamivudine）in the treatment of HBV-GN.Interferon-αis efficacious in remission of proteinuria,clearance of HBeAg and delay of renal function deterioration.Remission of proteinuria is often accompanied by clearance of HBV replication markers.Corticosteroid treatment could not improve renal outcome in patients with HBV-GN.

关 键 词：乙型肝炎病毒 肾炎 抗病毒治疗 

分 类 号：R512.62[医药卫生—内科学]