CLSI新判断标准下肠杆菌的耐药监测与比较  

The observation and comparison of Gram-negative bacilli resistance under CLSI new standard

作　　者：杨明明[1] 林立中[1] 邹飞扬[1] 夏先考[1] 

机构地区：[1]湖南常德市第一人民医院检验科,415000

出　　处：《检验医学与临床》2011年第12期1473-1474,共2页Laboratory Medicine and Clinic

摘　　要：目的比较新折点下的耐药监测,更好指导临床用药。方法双纸片增效法进行超广谱β-内酰胺酶法(ESBL)筛选及确证试验。K-B法和琼脂稀释法进行直径和肉汤稀释法(MIC)值测定后计算耐药率。结果新规则下总体耐药率升高,其中头孢噻肟耐药率高达67.0%,但与ESBL阳性规则下的耐药率比较,头孢他啶,氨曲南的敏感率显著提高,头孢他啶耐药率55.2%,氨曲南耐药率50.2%。结论多重耐药模式确证以前的规则不可靠,一部分不能使用的头孢他啶、氨曲南敏感率显著性提高,新规则下三代、四代头孢总体耐药率上升,使临床大量求助其他类型药物,给感染控制提出巨大挑战。Objective To compare the drug resistance observation under new broke-point,and in order to guide the clinical use of drugs.Methods We used the couble antimicrobial agents to detect Esbl comfirmatory,and K-B and MIC to test drug resistance.Results The total resistance rates increased,comparing the Esbl positive resistance rate,the sencetive rate of ceftazidime and Aztreonam rose oboviously,and the resistance rate of CAZ was 55.2% and 50.2% for CRO.Conclusion The multidrug resistance mode has proved that the rule before is not correct.Under the new broken-point,the increaseof drug resistance of the third and forth generation cephalosporins clinican shows that we should select to use other drug,which means that the great chanllenge is happen to hospital acquiuived infection.

关 键 词：肠杆菌 超广谱Β-内酰胺酶 细菌耐药率 

分 类 号：R378[医药卫生—病原生物学]