344株临床常见病原微生物分布及其耐药性分析  

Distribution and drug resistance analysis of 344 strains of common pathogenic microorganism

作　　者：吴财铭 孙延生[1] 栗俊杰[1] 陈莉[1] 

机构地区：[1]广东省深圳市蛇口人民医院检验科,518067

出　　处：《国际检验医学杂志》2011年第8期851-852,854,共3页International Journal of Laboratory Medicine

摘　　要：目的分析深圳市蛇口人民医院2008年11月至2009年10月临床感染的菌群分布情况及其耐药性。方法使用Microscan auto SCAN4半自动微生物鉴定仪进行检测。结果共分离细菌344株,其中革兰阳性球菌占34.59%,革兰阴性杆菌占65.41%,分离率由高至低依次为大肠埃希菌(24.71%)、肺炎克雷伯菌(11.05%)、表皮葡萄球菌(9.30%)、金黄色葡萄球菌(8.14%)、溶血葡萄球菌(5.52%)、铜绿假单胞菌(4.94%)、阴沟肠杆菌(4.07%)等;革兰阴性杆菌对抗菌剂敏感率依次为亚胺培南(87.60%)、阿米卡星(77.75%)、哌拉西林/他唑巴坦(75.55%)、头孢他啶(75.39%)、头孢吡肟(74.20%)、氨曲南(70.71%);革兰阳性球菌中未分离出耐万古霉素的菌株。结论革兰阴性杆菌分离率高于革兰阳性球菌,革兰阳性球菌对万古霉素敏感率为100.00%,革兰阴性杆菌对亚胺培南、阿米卡星和哌拉西林/他唑巴坦敏感率最高。Objective To investigate the distribution and drug resistance of common pathogenic microorganism in a hospital from Nov 2008 to Oct 2009. Methods Bacteria were identified by micro scan auto scan 4 microbiological system. Results 344 strains of pathogens were isolated,among which 34.59% were gram-positive cocci and 65.41% were gram-negative bacilli（65.41 %）. The isolation rates of common pathogens, ranged from high to low, were escherichia coil（ 24.71 % ）, klebsiella pneumoniae（ 11.05% ）, staphylococcus epidernidis（ 9.30 % ）, staphylococcus aureus （ 8. 14 % ）, staphylococcus haemolyticus （ 5.52 % ）, pseudomonas aerugimosa （ 4.94 % ）, and enterobacter cloacae（4.07 % ）. The sensitivity rates of gram-negative bacilli to imipenem, amikaein, piperaeillin/tazobactam, eeftazidime,cefepime and aztreonam were 87.60%,77.75%,75.55%,75.39%,74.20% and 70.71%, respectively. No vancomycin-resistant strain was isolated in gram-positive cocci. Conclusion The isolation rate of gram negative bacilli is higher than gram positive cocci, The sensitivity rate of gram-positive to vancomycin was 100.00% ,and gram-negative bacilli were relatively sensitive to imipenem, amikacin and piperacillin/tazobactam.

关 键 词：微生物敏感性试验 抗药性 菌群分布 

分 类 号：R446.5[医药卫生—诊断学]