不同剂量的曲马多对小鼠学习记忆的影响  

EFFECT OF TRAMADOL WITH DIFFERENT DOSES ON THE LEARNING MEMORY OF MICE

作　　者：严涛[1] 夏欢[1] 江维[1] 倪云成[1] 钱炜锋 魏鹏程[1] 费凡[1] 陶伟荣[1] 张洋[2] 

机构地区：[1]徐州医学院,江苏徐州221002 [2]徐州医学院麻醉生理学教研室,江苏徐州221002

出　　处：《井冈山大学学报（自然科学版）》2011年第3期118-120,共3页Journal of Jinggangshan University (Natural Science)

摘　　要：目的观察不同剂量曲马多对小鼠学习记忆的影响。方法将小鼠分为4组(n=10):生理盐水组(NS组)及曲马多5﹑10﹑20mg·kg-1组(TS1、TS2、TS3组),各组腹腔注射相应剂量的曲马多,随后分别进行跳台、避暗,以不同时间测定的潜伏期、错误次数作为评估小鼠学习记忆能力的指标。结果与NS组比较,跳台实验中TS3组小鼠的跳台潜伏期缩短与错误次数增加(P<0.05),避暗实验中TS3组的潜伏期缩短与错误次数增加(P<0.05)。结论在本实验条件下,20mg·kg-1剂量的曲马多能损害小鼠的记忆功能,记忆损害在停药一天后迅速消失,提示不会造成持久的记忆障碍。Objective：To observe the effect of tramadol with different doses on the learning memory of mice. Methods：Forty mice were randomly divided into four groups,saline group（NS）and tramadol group treated as 5﹑10﹑20 mg/kg （TS1,TS2,TS3 group）. The latency and error times in learning and memory test were conducted. Results：Compared with NS group,TS3 group showed shortening of latency and increase of errortimes in step-down test （P 0.05）. Shortening of latency and increase of error times in step-through test was showed in TS3 group （P 0.05）. Conclusion：Tramadol with the dose of 20 mg/kg may impair the memory function of mice,the memory impairment disappears quickly in one day after drug withdrawal,implying that persistent dysfunction in memory couldn＇t be caused.

关 键 词：曲马多 小鼠 跳台实验 避暗实验 学习记忆 

分 类 号：R971.1[医药卫生—药品]