N-[2,4-二取代-5-(3-甲基-2,6-二氧-4-三氟甲基-2,3-二氢嘧啶-1(6H)-基)苯基]磺酰胺类化合物的合成及生物活性研究  

Synthesis and Herbicidal Activity of N-[2,4-Disubstituted-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-2,3-dihydropyrimidin-1(6H)-yl)phenyl]Sulfamide

作　　者：陈仔玲[1,2] 黄明智[2] 徐满才[1] 任叶果[2] 胡志彬[2] 雷满香[2] 

机构地区：[1]湖南师范大学化学化工学院,湖南长沙410081 [2]湖南化工研究院国家农药创制工程技术研究中心,湖南长沙410007

出　　处：《精细化工中间体》2011年第2期17-20,27,共5页Fine Chemical Intermediates

基　　金：国家自然科学基金资助项目(20872033);国家973资助项目(2010CB126104);湖南省自然科学基金资助项目(10JJ3053);湖南省科技计划资助项目(2010FJ2003);科研条件创新资助项目(2010PF2058)

摘　　要：合成了9个N-[2,4-二取代-5-(3-甲基-2,6-二氧-4-三氟甲基-2,3-二氢嘧啶-1(6H)-基)苯基]酰胺类化合物。其化学结构经1H NMR、LC-MASS、IR元素分析确证。初步生物活性测定表明:标题化合物具有较好的除草活性,如在有效成分75 g/hm2剂量下,采取茎叶处理,化合物8b、8c对双子叶杂草苘麻、刺苋和藜的抑制率均不低于90%。Nine N-[2,4-Disubstituted-5-（3-methyl-2,6-dioxo-4-trifluoromethyl-2,3-dihydropyrimidin-1（6H）-yl） phenyl]sulfamides were designed and synthesized.Their structures were confirmed by 1H NMR,LC-MS,IR spectra and elemental analysis.The bioassay showed that the title compounds possessed reasonable herbicidal activities.For example,compounds 8b and 8c in post-emergence treatment exhibited not less than 90%inhibition against dicotyledon weeds,such as Abutilon theophrasti,Amaranthus spinosus and Chenopodium album at an active ingredient of 75 g/hm2.

关 键 词：脲嘧啶 磺酰胺 除草活性 

分 类 号：TQ455.4[化学工程—农药化工]