慢性重型乙型肝炎患者血清白介素-18与一氧化氮检测的临床意义  

Clinical significance of measuring serum IL-18 and NO in chronic severe hepatitis B

作　　者：彭晓明[1] 刘娅[2] 王煜[2] 向洪涛[1] 王海燕[1] 

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏医科大学附属医院感染疾病科,宁夏银川750004

出　　处：《现代医药卫生》2011年第12期1765-1766,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨慢性重型乙型肝炎血清中白介素-18与一氧化氮的水平检测的临床意义。方法:设立正常对照组42例、慢性乙型肝炎组36例和慢性重型乙型肝炎组31例,用ELISA方法检测血清中白介素-18水平,同时用硝酸还原酶法检测血清中一氧化氮水平,观察各组白介素-18和一氧化氮的水平。结果:慢性重型乙型肝炎组和慢性乙型肝炎组血清中白介素-18、一氧化氮水平较正常对照组均升高,慢性重型乙型肝炎组较慢性乙型肝炎组升高更显著,各组间比较均差异有统计学意义(P均<0.05)。结论:白介素-18、一氧化氮升高是慢性重型乙型肝炎病情加重的原因之一,检测血清中白介素-18、一氧化氮可作为判断慢性重型乙型肝炎患者病情严重程度的指标。Objective：To investigate the clinical significance of measuring the levels of serum IL-18 and NO in chronic severe hepatitis B patients.Methods：Serum IL-18 was detected by ELISA method and serum NO by nitrate reductase method in 42 cases of normal control,36 cases of chronic hepatitis B and 31 cases of chronic severe hepatitis B.The levels of serum IL-18 and NO were observed in each group.Results：The levels of serum IL-18 and NO in chronic severe hepatitis B group and chronic hepatitis B group were higher than those in the normal control group.The levels in chronic severe hepatitis B group were increased more significantly compared with chronic hepatitis B group.The comparison among various groups showed significant differences（P0.05）.Conclusion：The increasing of serum IL-18 and NO level is one of the reasons for exacerbations of chronic severe hepatitis B.Measuring the serum IL-18 and NO level could be used as the indicator to determine the severity degree of chronic severe hepatitis B patients.

关 键 词：慢性重型乙型肝炎 白介素-18 一氧化氮 

分 类 号：R5[医药卫生—内科学]