B型钠尿肽和超敏C反应蛋白在冠心病患者中的临床意义  

Research and clinical significance of blood BNP and hs-CRP in patients with coronary heart disease

作　　者：吴达党 

机构地区：[1]阳西县人民医院,广东阳西529800

出　　处：《现代医药卫生》2011年第12期1784-1786,共3页Journal of Modern Medicine & Health

摘　　要：目的:探讨B型钠尿肽(brain natriuretic peptide,BNP)与超敏C反应蛋白(hypersensitive C-reaction protein,hs-CRP)联合检测在冠状动脉硬化性心脏病中的应用价值。方法:将研究对象分为3组:稳定型心绞痛组、不稳定型心绞痛组和急性心肌梗死组,免疫化学发光法检测血清BNP,免疫比浊法测定血清hs-CRP。结果:不稳定型心绞痛和急性心肌梗死患者的BNP与hs-CRP水平均明显高于稳定型心绞痛及对照组,差异均具有统计学意义(P<0.01);治疗后不稳定型心绞痛和急性心肌梗死患者的BNP与hs-CRP水平显著下降,治疗前后hs-CRP与BNP两者水平呈正相关。结论:血清BNP和hs-CRP浓度的增高与冠状动脉硬化性心脏病(Coronaryheart disease,CHD)的病变程度相关,对判断CHD的严重程度有重要意义。Objective：To evaluate the value of combination detection of brain natriuretic peptide（BNP） and hypersensitive C-reaction protein（hs-CRP） in coronary heart disease（CHD）.Methods：The study subjects were divided into three groups： the stabilized angina pectoris group（SAP）,unsteady angina pectoris group（UAP） and acute myocardial infarction group（AMI）.The plasma levels of BNP and hs-CRP were measured with chemical luminescence immunoassay and immune turbidimetry respectively.Results：The concentrations of hs-CRP and BNP in the UAP and AMI groups were higher than those in SAP and normal control groups,showing statistical difference（P0.01）.The concentrations of hs-CRP and BNP in UAP and AMI groups were deceased significantly after effective therapy.The level of hs-CRP before and after treatment in CHD was positively correlated to BNP.Conclusion：The high level of hs-CRP and BNP is related to the degree of CHD and has great significance in judging the severe degree of CHD.

关 键 词：冠状动脉硬化性心脏病 B型钠尿钛 高敏C反应蛋白 

分 类 号：R446[医药卫生—诊断学]