动脉灌注栓塞术联合热疗治疗中晚期肝癌31例  

Transcatheter Arterial Chemoembolization Combined with Thermotherapy for Treating Mid-Late Stage Liver Cancer in 31 Cases

作　　者：彭杰[1] 胡章华[2] 杜驰[3] 

机构地区：[1]四川省内江市第一人民医院肿瘤科,四川内江641000 [2]四川省资阳市第一人民医院肿瘤科,四川资阳641300 [3]四川省内江市第二人民医院肿瘤科,四川内江641000

出　　处：《中国药业》2011年第11期50-51,共2页China Pharmaceuticals

摘　　要：目的探讨动脉灌注栓塞术(TACE)联合深部热疗治疗中晚期原发性肝癌的疗效及毒副反应。方法将63例患者随机分为治疗组31例和对照组32例,治疗组采用深部热疗加动脉灌注栓塞术,热疗每周2次,每次治疗间隔时间72 h以上,每5次热疗为1个疗程,对照组采用单纯动脉灌注栓塞术。热疗5次加介入治疗1次为1个疗程。评价患者疗效、生活质量和毒副反应。结果治疗组与对照组有效率分别为70.97%和46.88%,两组近期疗效比较差异有显著意义(P=0.029);两组治疗后生活质量有显著性差异(P=0.011);主要不良反应均为消化道反应和血液学毒性,两组之间毒性反应无明显差异。结论动脉灌注栓塞术联合热疗治疗原发性肝癌的疗效较好,可改善患者生活质量,且毒副反应低,值得临床推广。Objective To observe the efficacy and toxicity of transcatheter arterial chemoembolization（TACE） combined with thermotherapy for treating mid-late stage primary liver cancer.Methods Sixty-three patients with primary liver cancer were randomly divided into the treatment group（31 cases） and the control group（32 cases）.The treatment group was treated with deep thermotherapy combined with TACE.The thermotherapy was given twice a week after TACE with interval time of over 72 h,5 times for a treatment cycle.The control group was given TACE alone.The effective rate,quality of life and toxicity were evaluated between the two groups.Results The rate of response（RR） in treatment group and control group were 70.97%and 46.88%respective,showing significant differences in the short-term efficacy between the two groups（P=0.029）.The quality of life after treatment in both groups had significant difference（P=0.011）.The major adverse reactions were gastrointestinal and hematologic toxicity with no significant differences between the two groups.Conclusion TACE combined with thermotherapy has better efficacy and improves the quality of life for treating primary liver cancer with less adverse reactions,which is worthy of being popularized in clinic.

关 键 词：原发性肝癌 动脉灌注栓塞术 热疗 

分 类 号：R969.4[医药卫生—药理学] R735.7[医药卫生—药学]