2009年上海市甲型H1N1流感疫苗大规模人群接种免疫学效果评价  

Evaluation of influenza A(H1N1) vaccination effectiveness in Shanghai,2009

作　　者：顾宝柯[1] 于淼[2] 陈健[1] 蔡华[2] 袁政安[1] 王丹[2] 陈昕[3] 赵根明[2] 刘杰[1] 张涛[2] 

机构地区：[1]上海市疾病预防控制中心,上海200336 [2]复旦大学公共卫生学院公共卫生安全教育部重点实验室 [3]上海市卫生局

出　　处：《中国预防医学杂志》2011年第6期498-500,共3页Chinese Preventive Medicine

摘　　要：目的评价2009-2010年上海市甲型H1N1流行性感冒疫苗（甲流疫苗）的免疫学效果。方法以公安人员、中小学生、医务人员这三类重点人群作为免疫学评价的对象,采用分层抽样的方法在上海市4个区县抽取公安人员110人,中小学生146人,医务人员306人,于甲流疫苗接种前和接种后5~6周分别采集外周静脉血,检测甲型H1N1流感（甲流）抗体水平,进行甲流疫苗免疫学效果评价。结果总体上,甲流抗体阳性率由接种前34.9%提高到98.9%,抗体几何平均滴度（GMT）由接种前1∶17提高到1∶351,抗体≥4倍增长率为85.6%。结论 2009年上海市大规模人群接种的甲流疫苗具有良好的免疫学效果。Objective To evaluate the effectiveness of influenza A（H1N1） virus split vaccine on a mass-vaccination program.Methods A stratified sampling method was applied to select 110 public security staff,146 elementary and high school students and 306 health care professionals.All participants were tested for influenza A antibody levels before and in 5-6 weeks after the vaccination of influenza A（H1N1）.Results The positive rate of influenza A（H1N1） influenza antibody increased from 34.9% to 98.9% and the average titer of antibody increased from 1：17 to 1：351 for positive specimens after the vaccination.A four-fold increase of influenza antibody was observed in 85.6% of post-vaccination specimens.Conclusion The influenza A（H1N1） vaccine demonstrated good immunological effectiveness.

关 键 词：甲型H1N1流行性感冒 甲流疫苗 免疫学效果 

分 类 号：R186[医药卫生—流行病学] R511.7[医药卫生—公共卫生与预防医学]